Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
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Summary
This work validated the histochemical Sudan-Black-B (SBB) specific stain of lipofuscin, an aggregate of oxidized proteins, lipids and metals, known to accumulate in aged tissues, as an additional reliable approach to detect senescent cells independently of sample preparation, strongly supporting the candidacy of lip ofuscin for a biomarker of cellular senescence.
- Type
- article
- Published
- 2012-12-29
- Cited by
- 360
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1659141691
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11151294
Keywords
Lipofuscin, Senescence, Biomarker, Staining, Cell biology
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Cited by
- Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1
- Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis
- The Senescent Cell Induced Bystander Effect
- Interleukin33 Is Required for Disposal of Unnecessary Cells during Ovarian Atresia through Regulation of Autophagy and Macrophage Migration
- Low‐dose rotenone exposure induces early senescence leading to late apoptotic signaling cascade in human trabecular meshwork (HTM) cell line: An in vitro glaucoma model
- Cellular senescence: from physiology to pathology
- Geroconversion: irreversible step to cellular senescence
- α-Fucosidase as a novel convenient biomarker for cellular senescence
- Assessing benzene-induced toxicity on wild type Euglena gracilis Z and its mutant strain SMZ.
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- The value of muscle biopsies in Pompe disease: identifying lipofuscin inclusions in juvenile- and adult-onset patients
- Selective anti-cancer agents as anti-aging drugs
- Imaging of cellular aging in human retinal blood vessels.
- Senescence-associated inflammatory responses: aging and cancer perspectives.
- Loss of MT1‐MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
- Aging on a different scale – chronological versus pathology-related aging
- Gerosuppression in confluent cells
- Exploring and exploiting the systemic effects of deregulated replication licensing.
- Effects of chemotherapy and radiotherapy in rectal cancer : significance of different cellular outcomes in tumor behavior
- ATR-101 disrupts mitochondrial functions in adrenocortical carcinoma cells and in vivo
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