Ionic Currents and Spontaneous Firing in Neurons Isolated from the Cerebellar Nuclei
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Summary
It is proposed that, after the decay of high-threshold potassium currents, the tonic cation current contributes strongly to the depolarization of neurons above threshold, thus maintaining the cycle of firing.
- Type
- article
- Published
- 2000-12-15
- Cited by
- 243
- References
- 103
- Access
- Open access
- OpenAlex
- https://openalex.org/W1611130199
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1895052
Keywords
Depolarization, Tetrodotoxin, Biophysics, Neuroscience, Current clamp
References
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- Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
- Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus
- Identification and characterization of a Ca(2+)-sensitive nonspecific cation channel underlying prolonged repetitive firing in Aplysia neurons.
- The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons
- Muscarinic Receptor Activity Induces an Afterdepolarization in a Subpopulation of Hippocampal CA1 Interneurons
- Cerebellar nuclei: the olivary connection.
- Functional significance of excitatory projections from the precerebellar nuclei to interpositus and dentate nucleus neurons for mediating motor, premotor and parietal cortical inputs.
- Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons.
- Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro
- Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum.
- Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current.
- Differential expression of Shaw-related K+ channels in the rat central nervous system
- A voltage‐clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones.
- Electrophysiological characteristics of neurones in the guinea‐pig deep cerebellar nuclei in vitro.
- Na+ channels must deactivate to recover from inactivation.
- Two modes of gating during late Na+ channel currents in frog sartorius muscle
- A persistent sodium current in acutely isolated histaminergic neurons from rat hypothalamus.
Cited by
- Long-lasting increases in intrinsic excitability triggered by inhibition.
- Firing properties of GABAergic versus non-GABAergic vestibular nucleus neurons conferred by a differential balance of potassium currents.
- Respiratory rhythm generation: preBötzinger neuron discharge patterns and persistent sodium current.
- A Sodium Leak Current Regulates Pacemaker Activity of Adult Central Pattern Generator Neurons in Lymnaea Stagnalis
- Effects of Brief Electrical Stimulation on Embryonic Neurons Transplanted into Peripheral Nerve
- Cerebellar Nuclei and Cerebellar Learning
- Real-time methods in neural electrophysiology to improve efficacy of dynamic clamp
- Serotonergic modulation and its influence on signal processing at cellular level in deep cerebellar nuclei neurons
- Unique Features and Neuronal Properties in a Multisensory Cortex
- A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability
- Developmental expression of Na+ currents in mouse Purkinje neurons
- Analysis of distinct short and prolonged components in rebound spiking of deep cerebellar nucleus neurons
- A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets
- Persistent Changes in Spontaneous Firing of Purkinje Neurons Triggered by the Nitric Oxide Signaling Cascade
- Purkinje Cell Synapses Target Physiologically Unique Brainstem Neurons
- The Contribution of NMDA and AMPA Conductances to the Control of Spiking in Neurons of the Deep Cerebellar Nuclei
- Potassium and Sodium Currents Regulating Pacemaking and Burst Firing in Substantia Nigra Dopamine Neurons
- The studies on cystatin B deficient mice: neurochemical and behavioural alterations in animal model of progressive myoclonus epilepsy of Unverricht–Lundborg type
- Maturation of membrane properties of neurons in the rat deep cerebellar nuclei
- Age-related changes in the distribution of Kv1.1 and Kv1.2 channel subunits in the rat cerebellum.
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