Potassium and Sodium Currents Regulating Pacemaking and Burst Firing in Substantia Nigra Dopamine Neurons
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Summary
The goal was to understand the ionic currents that regulate spontaneous and burst firing in SNc neurons, using acutely dissociated somata from mouse SNc to describe major complementary contributions of largeconductance calcium-activated potassium (BK) channels and voltage-gated Kv2 channels.
- Type
- dissertation
- Published
- 2015-01-15
- Cited by
- 0
- References
- 210
- Access
- Open access
- OpenAlex
- https://openalex.org/W1854700337
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:94093252
Keywords
Substantia nigra, Dopamine, Neuroscience, Bursting, Potassium
References
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- ‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease
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- Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons
- Nifedipine‐ and omega‐conotoxin‐sensitive Ca2+ conductances in guinea‐pig substantia nigra pars compacta neurones.
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- The control of firing pattern in nigral dopamine neurons: single spike firing
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