A Sodium Leak Current Regulates Pacemaker Activity of Adult Central Pattern Generator Neurons in Lymnaea Stagnalis
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Summary
The Na+ leak conductance via the U-type channel, likely a NALCN-like channel, is identified as one of the fundamental mechanisms regulating rhythm activity of pacemaker neurons and respiratory behaviour in adult animals.
- Type
- article
- Published
- 2011-04-19
- Cited by
- 57
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W21526173
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2350349
Keywords
Root (linguistics), Control (management), Agronomy, Geography, Horticulture
References
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- Role of Inspiratory Pacemaker Neurons in Mediating the Hypoxic Response of the Respiratory Network In Vitro
- Ionic Currents and Spontaneous Firing in Neurons Isolated from the Cerebellar Nuclei
- Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels, through their Selective Coupling to Voltage-Gated Calcium Channels, Are Critical Determinants of the Precision, Pace, and Pattern of Action Potential Generation in Rat Subthalamic Nucleus Neurons In Vitro
- A transient network of intrinsically bursting starburst cells underlies the generation of retinal waves
- The ionic movements during nervous activity
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- Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na+ current and terminated by a slow Ca2+‐activated K+ current
- Activity-independent coregulation of IA and Ih in rhythmically active neurons.
- Extracellular Calcium Controls Background Current and Neuronal Excitability via an UNC79-UNC80-NALCN Cation Channel Complex
- Potassium Leakage From an Active Nerve Fibre
- A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans
- The respiratory central pattern generator of Lymnaea: a model, measured and malleable.
Cited by
- A genetic suppressor screen identifies a novel, conserved ion channel complex as a new downstream target of RHO-1 signalling
- The sodium leak channel, NALCN, in health and disease
- NALCN: A Regulator of Pacemaker Activity
- De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay.
- Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism
- NALCN Ion Channels Have Alternative Selectivity Filters Resembling Calcium Channels or Sodium Channels
- Behavioural and network plasticity following conditioning of the aerial respiratory response of a pulmonate mollusc1
- Sodium Leak Channels in Neuronal Excitability and Rhythmic Behaviors
- Caltubin, a Novel Molluscan Tubulin-Interacting Protein, Promotes Axonal Growth and Attenuates Axonal Degeneration of Rodent Neurons
- Involvement of Na+-leak Channel in Substance P-induced Depolarization of Pacemaking Activity in Interstitial Cells of Cajal
- Food deprivation and nicotine correct akinesia and freezing in Na+‐leak current channel (NALCN)‐deficient strains of Caenorhabditis elegans
- NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion.
- A uniquely adaptable pore is consistent with NALCN being an ion sensor
- Ca2+ channels and Praziquantel: a view from the free world
- The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion
- High Prevalence of Multistability of Rest States and Bursting in a Database of a Model Neuron
- De novo Mutations in NALCN Cause a Syndrome of Congenital Contractures of the Limbs and Face with Hypotonia, and Developmental Delay
- Sodium leak channel, non-selective contributes to the leak current in human myometrial smooth muscle cells from pregnant women.
- A Conserved Family of ER Proteins NLF Regulate the Na+ Leak Channel NCA/NALCN in Caenorhabditis elegans and Mus musculus
- A novel homozygous splice site mutation in NALCN identified in siblings with cachexia, strabismus, severe intellectual disability, epilepsy and abnormal respiratory rhythm.