Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
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Summary
A Ca2+-dependent modulation of the hyperpolarization-activated cation current (Ih) controls the slow recurrence of synchronized thalamocortical activity through persistent activation of Ih that may outlast the presence of increased free [Ca2+]i and [cAMP]i.
- Type
- article
- Published
- 1999-07-01
- Cited by
- 143
- References
- 43
- OpenAlex
- https://openalex.org/W1531289420
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17306481
Keywords
Stimulation, Neuroscience, Hyperpolarization (physics), Modulation (music), Chemistry
References
- Periodicity of thalamic spindle waves is abolished by ZD7288,a blocker of Ih.
- H-current: properties of a neuronal and network pacemaker.
- Generalized Epilepsy: Neurobiological Approaches
- Neurotransmitter Activation of Inwardly Rectifying Potassium Current in Dissociated Hippocampal CA3 Neurons: Interactions among Multiple Receptors
- Correction for liquid junction potentials in patch clamp experiments.
- Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
- A family of hyperpolarization-activated mammalian cation channels
- Voltage‐activated intracellular calcium transients in thalamic relay cells and interneurons
- Periodicity of thalamic synchronized oscillations: the role of Ca2+-mediated upregulation of Ih.
- Direct activation of cardiac pacemaker channels by intracellular cyclic AMP
- Differential Expression of Type I, II, and V Adenylyl Cyclase Gene in the Postnatal Developing Rat Brain
- Cellular mechanisms of a synchronized oscillation in the thalamus.
- Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.
- Biologically useful chelators that take up calcium(2+) upon illumination
- RMI 12330 A, an inhibitor of adenylate cyclase in rat liver.
- The multifunctional calcium/calmodulin-dependent protein kinase: from form to function.
- Transcriptional regulation by cyclic AMP.
- Photolytic manipulation of Ca2+ and the time course of slow, Ca(2+)‐activated K+ current in rat hippocampal neurones.
- Properties of a hyperpolarization‐activated cation current and its role in rhythmic oscillation in thalamic relay neurones.
- Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation.
Cited by
- H-Channel Dysfunction in Generalized Epilepsy: It Takes Two
- Heterogeneity in low voltage‐activated Ca2+ channel‐evoked Ca2+ responses within neurons of the thalamic paraventricular nucleus
- Episodic Waveforms in the Electroencephalogram during General Anaesthesia: A Study of Patterns of Response to Noxious Stimuli
- The sleep relay—the role of the thalamus in central and decentral sleep regulation
- Mechanisms of Multistability in Neuronal Models
- Spiking-bursting activity in the thalamic reticular nucleus initiates sequences of spindle oscillations in thalamic networks.
- Organization and regulation of neuronal intrinsic properties in the spiral ganglion
- Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations.
- Regulation of potassium currents in the sino-atrial node
- Duty Cycle Maintenance in an Artificial Neuron
- GABA signaling in the thalamus
- GABAergic mechanisms in absence epilepsy: a computational model of absence epilepsy simulating spike and wave discharges after vigabatrin in WAG/Rij rats
- Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis
- HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications
- Intrinsic Membrane Properties Underlying Spontaneous Tonic Firing in Neostriatal Cholinergic Interneurons
- Cortical and subcortical generators of normal and abnormal rhythmicity.
- Ionic Currents and Spontaneous Firing in Neurons Isolated from the Cerebellar Nuclei
- Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability
- Ih Channels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain
- Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels
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