Glutaminolysis and Transferrin Regulate Ferroptosis
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Summary
Inhibition of glutaminolysis, the essential component of ferroptosis, can reduce heart injury triggered by ischemia-reperfusion, suggesting a potential therapeutic approach for treating related diseases.
- Type
- article
- Published
- 2015-07-09
- Cited by
- 1,871
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1589007430
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5490495
Keywords
Glutaminolysis, Biology, Glutamine, Transferrin, Cell biology
References
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- Regulation of Ferroptotic Cancer Cell Death by GPX4
- Aldose reductase mediates myocardial ischemia-reperfusion injury in part by opening mitochondrial permeability transition pore.
- The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
- Chronic non-spherocytic hemolytic anemia associated with severe neurological disease due to γ-glutamylcysteine synthetase deficiency in a patient of Moroccan origin
- Antioxidant Determinations by the Use of a Stable Free Radical
- Ngamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site.
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Cited by
- Glutaminolysis as a target for cancer therapy
- Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
- Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists
- Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
- Iron and Cancer
- Regulation of alternative splicing through coupling with transcription and chromatin structure.
- Ferroptosis: Death by Lipid Peroxidation.
- Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
- Ferroptosis: process and function
- Iron and cancer: recent insights
- Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects
- Regulated necrosis: disease relevance and therapeutic opportunities
- Emerging roles for lipids in non-apoptotic cell death
- Mechanisms of ferroptosis
- An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model
- ROS homeostasis and metabolism: a dangerous liason in cancer cells
- Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response
- An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury.
- Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
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