Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Summary
It is demonstrated that ferroptosis is a pervasive and dynamic form of cell death, which, when impeded, promises substantial cytoprotection.
- Type
- article
- Published
- 2014-11-17
- Cited by
- 3,356
- References
- 47
- OpenAlex
- https://openalex.org/W2035898183
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1116828
Keywords
GPX4, Programmed cell death, Cell biology, Cytoprotection, Apoptosis
References
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Cited by
- Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
- Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells
- Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium
- Ferroptosis: The Greasy Side of Cell Death.
- Cell–cell contacts protect against t-BuOOH-induced cellular damage and ferroptosis in vitro
- The mechanisms behind heatstroke-induced intestinal damage
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- Ferroptosis is Involved in Acetaminophen Induced Cell Death
- The Impact of Regulated Cell Death Pathways on Alloimmune Responses and Graft Injury
- Selenocysteine oxidation in glutathione peroxidase catalysis: an MS-supported quantum mechanics study.
- Immune Regulation by Dead Cell Clearance.
- The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis.
- Glutaminolysis and Transferrin Regulate Ferroptosis
- Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
- Necroinflammation in Kidney Disease.
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- Using Small Molecules to Dissect Non‐apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis
- Glutathione peroxidase 4, a unique antioxidant enzyme, plays a role in protecting ocular surface mucosal epithelia.
- Designing drugs that combat kidney damage
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