Glutaminolysis as a target for cancer therapy
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Summary
This review summarizes current findings on the role of glutaminolytic enzymes in human cancers and provides an update on the development of small molecule inhibitors to target glutAMinolysis for cancer therapy.
- Type
- article
- Published
- 2015-11-23
- Cited by
- 392
- References
- 91
- Access
- Open access
- OpenAlex
- https://openalex.org/W26592449
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30163476
Keywords
Floristics, Geography, Ecology, Biology, Species richness
References
- Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells
- Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
- The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.
- Targeting glutamine transport to suppress melanoma cell growth
- Glutaminolysis and Transferrin Regulate Ferroptosis
- MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
- Targeting SLC1A5-mediated glutamine dependence in non-small cell lung cancer
- HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.
- Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma
- Action at a distance: allostery and the development of drugs to target cancer cell metabolism.
- Modulation of oxidative stress as an anticancer strategy
- Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition
- Green Tea Polyphenols Modulate Insulin Secretion by Inhibiting Glutamate Dehydrogenase*
- How cancer metabolism is tuned for proliferation and vulnerable to disruption
- An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.
- Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?
- Glutaminolysis and glycolysis regulation by troglitazone in breast cancer cells: Relationship to mitochondrial membrane potential
- Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation.
- Untangling the glutamate dehydrogenase allosteric nightmare.
- Glutaminolysis activates Rag-mTORC1 signaling.
Cited by
- Glutamine at focus: versatile roles in cancer
- Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches
- PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence
- Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP(+)-linked-polyhydroxybenzoates.
- Who watches the watchmen? Regulation of the expression and activity of sirtuins
- Differentially expressed mitochondrial genes in breast cancer cells: Potential new targets for anti-cancer therapies.
- Specific Detection of Cellular Glutamine Hydrolysis in Live Cells Using HNCO Triple Resonance NMR.
- Pheochromocytoma: The First Metabolic Endocrine Cancer
- TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade.
- Establishment of monoclonal antibodies against cell surface domains of ASCT2/SLC1A5 and their inhibition of glutamine-dependent tumor cell growth.
- May glutamine addiction drive the delivery of antitumor cisplatin-based Pt(IV) prodrugs?
- Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.
- Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties.
- Feasibility and antitumor efficacy in vivo, of simultaneously targeting glycolysis, glutaminolysis and fatty acid synthesis using lonidamine, 6-diazo-5-oxo-L-norleucine and orlistat in colon cancer.
- Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
- Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium
- Mitochondria and cancer chemoresistance.
- Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro.
- Kinetic analysis, size profiling, and bioenergetic association of DNA released by selected cell lines in vitro
- [The cancer paradigm in pulmonary arterial hypertension: towards anti-remodeling therapies targeting metabolic dysfunction?]
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