Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases1
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Summary
LXA4 in activated SF inhibits the synthesis of inflammatory cytokines and MMP and stimulates TIMP production in vitro, suggesting that LXA4 may be involved in a negative feedback loop opposing inflammatory cytokine-induced activation of SF.
- Type
- article
- Published
- 2000-03-01
- Cited by
- 221
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W1565755899
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43624910
Keywords
Matrix metalloproteinase, Metalloproteinase, Chemistry, Cell biology, Cancer research
References
- Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies.
- Production of interleukin-6 by synovial fibroblasts in rheumatoid arthritis.
- Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.
- Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.
- Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.
- Lipid mediator networks in cell signaling: update and impact of cytokines 1
- Lipoxin biosynthesis and its impact in inflammatory and vascular events.
- Interleukin 6 Is Required for the Development of Collagen-induced Arthritis
- Interaction(s) between essential fatty acids, eicosanoids, cytokines, growth factors and free radicals: relevance to new therapeutic strategies in rheumatoid arthritis and other collagen vascular diseases.
- Lipoxin A4 inhibits phosphoinositide hydrolysis in human neutrophils.
- Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1α–initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine–Chemokine Axis
- Lipoxin A4: a new class of ligand for the Ah receptor.
- Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction.
- Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.
- Interleukin 6 plays a key role in the development of antigen-induced arthritis.
- Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor*
- In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes.
- Interleukin‐6 and soluble interleukin‐6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast‐like cell formation
- Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?
- Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts
Cited by
- Lipoxins: update and impact of endogenous pro-resolution lipid mediators.
- Old and new generation lipid mediators in acute inflammation and resolution.
- Molecular biology for formyl peptide receptors in human diseases
- Estrogen Regulation of the 15-LOX/LXA4 Protective Lipid Circuit in the Corneal Inflammatory-Reparative Response
- Regulation of the matrix metalloproteinase matrilysin in human prostate carcinoma in vitro
- Perfil de citocinas inflamatórias em indivíduos submetidos a procedimentos cirúrgicos utilizando propofol ou isoflurano
- COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance.
- A Proinflammatory Role for the Cyclopentenone Prostaglandins at Low Micromolar Concentrations: Oxidative Stress-Induced Extracellular Signal-Regulated Kinase Activation Without NF-κB Inhibition1
- Fatty Acid Metabolism Mediated by 12/15-Lipoxygenase is a Novel Regulator of Hematopoietic Stem Cell Function and Myelopoiesis
- Efectos protectores de los Ácidos grasos Omega-3 en el hígado y el tejido adiposo
- Novel pathways and endogenous mediators in anti-inflammation and resolution.
- IL-6 and Matrix Metalloproteinase-1 Are Regulated by the Cyclin-Dependent Kinase Inhibitor p21 in Synovial Fibroblasts1
- ATL‐1, an analogue of aspirin‐triggered lipoxin A4, is a potent inhibitor of several steps in angiogenesis induced by vascular endothelial growth factor
- Annexin-1 Mediates TNF-α-Stimulated Matrix Metalloproteinase Secretion from Rheumatoid Arthritis Synovial Fibroblasts1
- Lipoxins: resolutionary road
- Lipoxin A4: Anti-Inflammatory and Anti-Angiogenic Impact on Endothelial Cells1
- ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis1
- Impaired phagocytic mechanism in annexin 1 null macrophages
- Metabolic profiling reveals differences in concentrations of oxylipins and fatty acids secreted by the infrapatellar fat pad of donors with end-stage osteoarthritis and normal donors.
- Resolvins and protectins: mediating solutions to inflammation
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