Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor*
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Summary
Results indicate that the LXA 4 stable analogs are potent monocyte chemoattractants and are more potent than native LXA4 in stimulating THP-1 cell adherence, at subnanomolar concentrations.
- Type
- article
- Published
- 1997-03-14
- Cited by
- 298
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W2037697142
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31181385
Keywords
Lipoxin, THP1 cell line, Receptor, Chemistry, Cell biology
References
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- Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells.
- Lipid mediator networks in cell signaling: update and impact of cytokines 1
- Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain.
- Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils.
- Lipoxin biosynthesis and its impact in inflammatory and vascular events.
- Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis.
- Amide and l-amino derivatives of F prostaglandins as prostaglandin antagonists
- Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction.
- Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers.
- Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.
- Detection of C5a receptors on human eosinophils and inhibition of eosinophil effector functions by anti‐C5a receptor (CD88) antibodies
- Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products.
- Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor
- Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: Dissociation between lipid remodeling and adhesion
- Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator
- Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction
Cited by
- Lipoxins: update and impact of endogenous pro-resolution lipid mediators.
- F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling.
- Old and new generation lipid mediators in acute inflammation and resolution.
- Lipoxin A4 and 15-Epi-Lipoxin A4 Protect against Experimental Cerebral Malaria by Inhibiting IL-12/IFN-γ in the Brain
- The Role of Lipids Mediators in Inflammation and Resolution
- Can inflammation be resolved in Alzheimer’s disease?
- Lipoxins, aspirin-triggered 15-epi-lipoxin stable analogs and their receptors in anti-inflammation: a window for therapeutic opportunity.
- Arachidonate Remodeling and Inflammation
- Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
- Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways.
- ETUDE DE LA REGULATION DES RECEPTEURS DE PEPTIDES N-FORMYLES
- Specialised lipid mediators and their targets.
- The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer
- The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor.
- Fatty Acid Metabolism Mediated by 12/15-Lipoxygenase is a Novel Regulator of Hematopoietic Stem Cell Function and Myelopoiesis
- Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages1
- Involvement of the Rho-Kinase/Myosin Light Chain Kinase Pathway on Human Monocyte Chemotaxis Induced by ATL-1, an Aspirin-Triggered Lipoxin A4 Synthetic Analog1
- Novel pathways and endogenous mediators in anti-inflammation and resolution.
- Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity
- Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases1
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