Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.
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Summary
The multiple interaction of lipoxygenases generates compounds that can regulate specific cellular responses of importance in inflammation and immunity.
- Type
- review
- Published
- 1987-09-04
- Cited by
- 2,167
- References
- 66
- OpenAlex
- https://openalex.org/W2024176341
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43753152
Keywords
Arachidonic acid, Leukotriene, Leukotriene B4, Leukotriene C4, Chemistry
References
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- Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding.
- Identification of a high affinity leukotriene C4-binding protein in rat liver cytosol as glutathione S-transferase.
- On the mechanism of the biosynthesis of prostaglandins E-1 and F-1-alpha.
- On the organization and mechanism of prostaglandin synthetase.
- Evidence for a 5(6)‐epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes
- Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids.
- Leukotriene D4: cardiovascular and sympathetic effects in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats.
- On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors.
- Leukotrienes in the rat central nervous system.
- Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction.
- Coronary vasoconstriction and PGI2 release by leukotrienes in isolated guinea pig hearts
- Antagonism of antigen-induced contraction of guinea pig and human airways
- Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro
- Formation of leukotriene C4-like material by rat brain tissue.
- Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
- A stereoselective and practical synthesis of 5,6(S,S)-epoxy-15(S)-hydroxy-7(E),9(E),11(Z),13(E)-eicosatetraenoic acid (4), possible precursor of the lipoxins
- Bronchoconstriction produced in man by leukotrienes C and D.
- Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.
Cited by
- Recovery of leukotriene E4 from the urine of patients with airway obstruction.
- Platelet-activating factor receptor and signal transduction.
- Increased pulmonary production of immunoreactive 15-hydroxyeicosatetraenoic acid in an animal model of asthma.
- Leukocyte inhibitory factor activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes.
- The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor
- Lipoxins: update and impact of endogenous pro-resolution lipid mediators.
- Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes.
- Essential fatty acids and immune response
- Molecular characterization of L2 lipoxygenase from maize embryos
- Human red cells enhance the formation of 5-lipoxygenase-derived products by neutrophils.
- Relation between Essential Fatty Acid Metabolism and Gastrointestinal Symptoms in Cystic Fibrosis
- Discovery and characterization of inflammation-induced electrophilic fatty acid derivatives
- The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes (*)
- Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils.
- Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells.
- Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.
- The lipoxin biosynthetic circuit and their actions with human neutrophils.
- Serum factors regulate 5-lipoxygenase activity in maturating HL60 cells.
- Energy-dependent export of leukotriene B4 in Xenopus oocytes.
- Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.
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