Lipoxins: resolutionary road
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Summary
An update of the biosynthesis, metabolism and bioactions of LXs and LX analogues, and the recent studies on their therapeutic potential as promoters of resolution and fibro‐suppressants are provided.
- Type
- review
- Published
- 2009-10-01
- Cited by
- 235
- References
- 144
- Access
- Open access
- OpenAlex
- https://openalex.org/W1601517895
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25202863
Keywords
Inflammation, Lipid signaling, Endogeny, Cell biology, Biology
References
- Lipoxin A. Stereochemistry and biosynthesis.
- Lipid mediator class switching during acute inflammation: signals in resolution
- Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.
- Lipoxin, leukotriene, and PDGF receptors cross‐talk to regulate mesangial cell proliferation
- Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking1
- Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages1
- Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.
- Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis1
- Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity
- Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors.
- ATL‐1, an analogue of aspirin‐triggered lipoxin A4, is a potent inhibitor of several steps in angiogenesis induced by vascular endothelial growth factor
- Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases1
- The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1.
- Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.
- Annexin-1 and Peptide Derivatives Are Released by Apoptotic Cells and Stimulate Phagocytosis of Apoptotic Neutrophils by Macrophages1
- Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases.
- Lipoxin A4 Redistributes Myosin IIA and Cdc42 in Macrophages: Implications for Phagocytosis of Apoptotic Leukocytes1
- Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells.
- Lipoxin A4: Anti-Inflammatory and Anti-Angiogenic Impact on Endothelial Cells1
- T21/DP107, A synthetic leucine zipper-like domain of the HIV-1 envelope gp41, attracts and activates human phagocytes by using G-protein-coupled formyl peptide receptors.
Cited by
- The Role of Lipids Mediators in Inflammation and Resolution
- Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease
- Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins
- A multifunctional nanoparticle for efferocytosis and pro-resolving-mediated endometriosis therapy.
- Evaluation of the Anti-Inflammatory Effects of Novel Pirinixic Acid Derivatives
- Estrogen Regulation of the 15-LOX/LXA4 Protective Lipid Circuit in the Corneal Inflammatory-Reparative Response
- Fishmeal Supplementation During Gestation and Lactation Protects Offspring Against Maternal Simulated Infection Induced Programming
- Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
- Specialised lipid mediators and their targets.
- Maresin 1 Prevents Lipopolysaccharide-Induced Neutrophil Survival and Accelerates Resolution of Acute Lung Injury
- Mechanisms for anti‐inflammatory effects of 1‐[15(S)‐hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A‐induced peritonitis
- Lipoxin A4 suppresses the development of endometriosis in an ALX receptor‐dependent manner via the p38 MAPK pathway
- Targeting granulocyte apoptosis: mechanisms, models, and therapies
- Maresin 1 mitigates LPS‐induced acute lung injury in mice
- Studies on the Regulation of Leukotriene Biosynthesis in Antigen Presenting Cells
- Bioactive Lipids in Trypanosoma cruzi Infection
- Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report.
- Prevention of Sports Injuries by Marine Omega-3 Fatty Acids
- Lipoxins: nature’s way to resolve inflammation
- Chemoattractant receptors in drug discovery: FPR2 and CCR2-two potential targets
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