Cancer-epigenetics comes of age
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Summary
Current mechanistic understanding of the role of DNA methylation in malignant transformation is reviewed, and it is suggested Knudson's two–hit hypothesis should be expanded to include epigenetic mechanisms of gene inactivation.
- Type
- review
- Published
- 1999-02-01
- Cited by
- 2,545
- References
- 76
- OpenAlex
- https://openalex.org/W1556996865
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10328397
Keywords
Biology, Epigenetics, DNA methylation, Cancer epigenetics, Genetics
References
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Cited by
- Bio-COBRA: absolute quantification of DNA methylation in electrofluidics chips.
- Biological signature of HER2-positive breast cancer
- Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications
- CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA methylation status and multiple alternative first exons.
- Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma.
- Trends in biomarker research for cancer detection.
- DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair
- Molecular Genetic Studies of Chromosome 8 and Oncogene c-myc in Breast Cancer
- Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma.
- Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
- DNA methylation changes in gastrointestinal disease
- Down-Regulation of Connexin 32 Gene Expression through DNA Methylation in a Human Renal Cell Carcinoma Cell
- Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma
- Hypermethylation of a Small CpGuanine-Rich Region Correlates with Loss of Activator Protein-2α Expression during Progression of Breast Cancer
- Epigenetic events in the colorectum and in colon cancer.
- Hypermethylation of 18S and 28S Ribosomal DNAs Predicts Progression-Free Survival in Patients with Ovarian Cancer
- Molecular Characterization of Head and Neck Cancer: How Close to Personalized Targeted Therapy?
- Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders
- Urothelial carcinomas arising in arsenic‐contaminated areas are associated with hypermethylation of the gene promoter of the death‐associated protein kinase
- Characteristic methylation profile in CpG island methylator phenotype‐negative distal colorectal cancers
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