Defective mismatch-repair as a minor tumorigenic pathway in Barrett esophagus-associated adenocarcinoma.
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Summary
The findings suggest that only a small subset of Barrett adenocarcinomas develop because of defective MMR, but demonstrate that MLH1 and MSH2 are the primary targets for defective MMR also in this tumor type.
- Type
- article
- Published
- 2005-02-01
- Cited by
- 23
- References
- 18
- OpenAlex
- https://openalex.org/W2002777462
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23318968
Keywords
MSH2, MLH1, Microsatellite instability, DNA mismatch repair, Biology
References
- The relationship between columnar epithelial dysplasia and invasive adenocarcinoma arising in Barrett's esophagus.
- Recent Developments in the Molecular Characterization of Barrett’s Esophagus
- Ubiquitous somatic alterations at microsatellite alleles occur infrequently in Barrett's-associated esophageal adenocarcinoma.
- Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction.
- Infrequent microsatellite instability in oesophageal cancers.
- Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine
- Microsatellite instability in cancer of the proximal colon.
- Gastrointestinal cancer of the microsatellite mutator phenotype pathway
- Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus‐associated adenocarcinoma
- Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer?
- Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review.
- New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.
- Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.
- A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.
- Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.
- Barrett's esophagus and adenocarcinoma.
- Barrett esophagus and adenocarcinoma.
- Microsatellite instability occurs frequently and in both diploid and aneuploid cell populations of Barrett's-associated esophageal adenocarcinomas.
Cited by
- The molecular biology of esophageal adenocarcinoma
- Microsatellite instability analysis and its correlation with hMLH1 repair gene hypermethylation status in esophageal pathologies including cancers
- Inflammation and Barrett's carcinogenesis.
- A homozygote splice site PMS2 mutation as cause of Turcot syndrome gives rise to two different abnormal transcripts
- Targeting chemokine pathways in esophageal adenocarcinoma
- Barrett’s oesophagus: an ideal model to study cancer genetics
- Hereditary Factors in Esophageal Adenocarcinoma
- Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma
- Clinicopathologic and Molecular Profiles of Microsatellite Unstable Barrett Esophagus-associated Adenocarcinoma
- High intratumoural but not peritumoural inflammatory host response is associated with better prognosis in primary resected oesophageal adenocarcinomas.
- Morphological Features and Prognostic Significance of ARID1A-Deficient Esophageal Adenocarcinomas.
- Epstein-Barr virus and mismatch repair deficiency status differ between oesophageal and gastric cancer: A large multi-centre study
- Pharmacotherapy for metastatic esophageal cancer: where do we need to improve?
- Predictive and prognostic implications of microsatellite instability and mismatch repair deficiency in carcinomas of the gastrointestinal tract, liver, and pancreas
- Loss of ARID1A expression is associated with DNA mismatch repair protein deficiency and favorable prognosis in advanced stage surgically resected esophageal adenocarcinoma.
- Prognostic and therapeutic molecular markers in the clinical management of esophageal cancer
- Gastrointestinal cancers: current biomarkers in esophageal and gastric adenocarcinoma.
- Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma
- Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center
- Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome
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