N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
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Summary
Data suggest that N‐myc genes function as major regulators of the protein synthesis machinery in neuroblastomas.
- Type
- article
- Published
- 2001-03-15
- Cited by
- 444
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2071491707
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34637103
Keywords
Biology, Ribosome biogenesis, Gene, Ribosome, Gene expression
References
- Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.
- c‐myc down‐regulates class I HLA expression in human melanomas.
- The MYC protein activates transcription of the alpha‐prothymosin gene.
- Proteins of the Myc network: essential regulators of cell growth and differentiation.
- Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
- Identification of a Myc‐dependent step during the formation of active G1 cyclin‐cdk complexes.
- Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum.
- Myc‐Max heterodimers activate a DEAD box gene and interact with multiple E box‐related sites in vivo.
- Structure and functions of nucleolin.
- The ornithine decarboxylase gene is a transcriptional target of c-Myc.
- Drosophila myc regulates cellular growth during development.
- Major nucleolar proteins shuttle between nucleus and cytoplasm.
- Nucleolin functions in the first step of ribosomal RNA processing
- Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein.
- Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
- The role of c-myc in cellular growth control
- Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.
- c-Myc enhances protein synthesis and cell size during B lymphocyte development.
- Targeted expression of MYCN causes neuroblastoma in transgenic mice
- Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo.
Cited by
- N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.
- Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.
- Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells.
- Rôle de l'ETP Corto et de la protéine ribosomique RPL12 dans la régulation transcriptionnelle chez Drosophila melanogaster
- Sperm RNA elements as markers of health
- Regulation of milk fat synthesis by dietary fatty acids.
- Myc target transcriptomes.
- Classification of Pediatric Tumors Using DNA Microarrays
- The myc oncogene: MarvelouslY Complex.
- Myc-mediated control of gene transcription in cancer cells
- Sauerstoffverbrauchsmessungen an humanen Neuroblastomzellen und an isolierten Mitochondrien
- Inference on biological mechanisms using an integrated phenotype prediction model.
- [Genetic alterations in neuroblastoma and their usefulness for clinical management].
- Serial Analysis of Gene Expression (SAGE) in Cancer Research
- Ribosomal proteins and colorectal cancer.
- The translation factor eIF5A and human cancer
- Drosophila Low Temperature Viability Protein 1 (LTV1) Is Required for Ribosome Biogenesis and Cell Growth Downstream of Drosophila Myc (dMyc)*
- Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins
- Identification and characterization of eukaryotic initiation factor 5A-2.
- Control of mRNA Translation in Erythropoiesis
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