Mitochondria Positioning Controls Local Calcium Influx in T Cells
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Summary
Local calcium entry rather than global calcium entry is the preferential mechanism of calcium entry at stable ISs in Th cells, and mitochondria are preferentially translocated to the IS in a calcium influx-dependent manner but independent of the exact calcium influx site.
- Type
- article
- Published
- 2009-12-14
- Cited by
- 114
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W1550719001
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33762852
Keywords
Calcium, Cell biology, Chemistry, Mitochondrion, Voltage-dependent calcium channel
References
- STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
- Three-dimensional segregation of supramolecular activation clusters in T cells
- T‐cell activation through immunological synapses and kinapses
- STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
- Centrosome polarization delivers secretory granules to the immunological synapse
- T cells use two directionally distinct pathways for cytokine secretion
- Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation
- Local Ca2+ Influx through Ca2+ Release-activated Ca2+ (CRAC) Channels Stimulates Production of an Intracellular Messenger and an Intercellular Pro-inflammatory Signal*
- T cell activation requires mitochondrial translocation to the immunological synapse
- Calcium dependence of T cell proliferation following focal stimulation
- Apparent cytosolic calcium gradients in T-lymphocytes due to fura-2 accumulation in mitochondria.
- Sustained Activity of Calcium Release-activated Calcium Channels Requires Translocation of Mitochondria to the Plasma Membrane*
- Lymphocyte responses and cytokines.
- The functional network of ion channels in T lymphocytes
- The immunological synapse controls local and global calcium signals in T lymphocytes
- Shouts, whispers and the kiss of death: directional secretion in T cells
- Morphological changes of T cells following formation of the immunological synapse modulate intracellular calcium signals.
- Microdomains of intracellular Ca2+: molecular determinants and functional consequences.
- Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo
- Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
Cited by
- Role of cytoskeletal remodeling in T cell receptor signaling and integrin activation at the immunological synapse
- Store-Operated Ca²⁺ Entry (SOCE) Pathways
- Optogenetic Control of Molecular Motors and Organelle Distributions in Cells
- STIM1 is required for attenuation of PMCA‐mediated Ca2+ clearance during T‐cell activation
- Store-Operated Calcium Channels.
- The mitochondrial fission factor dynamin‐related protein 1 modulates T‐cell receptor signalling at the immune synapse
- The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux.
- Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
- Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes.
- Mitochondria take up Ca2+ in two steps dependently on store-operated Ca2+ entry in mast cells.
- Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review
- Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.
- Mitochondrial dynamics and their impact on T cell function.
- A role for mitochondria in antigen processing and presentation
- METABOLIC REGULATION OF ORGANELLE HOMEOSTASIS IN LUPUS T CELLS
- Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses
- Physiological roles of mitochondrial reactive oxygen species
- Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling*
- Signaling pathways in aged T cells – a reflection of T cell differentiation, cell senescence and host environment
- Induction of PGC-1α Expression Can Be Detected in Blood Samples of Patients with ST-Segment Elevation Acute Myocardial Infarction
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