Calcium dependence of T cell proliferation following focal stimulation
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Summary
It is concluded that very small changes in [Ca2+]i can dramatically change the ratio between proliferation and apoptosis, thus keeping the balance between overshooting and inefficient immune responses.
- Type
- article
- Published
- 2007-10-01
- Cited by
- 65
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2010109058
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6804295
Keywords
Immunological synapse, Biology, Apoptosis, Stimulation, Cell biology
References
- The intracellular Ca2+ concentration optimal for T cell activation is quite different after ionomycin or CD3 stimulation
- STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
- Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
- The molecular choreography of a store-operated calcium channel
- Calcium fluxes in T lymphocytes.
- Modulation of plasma membrane calcium‐ATPase activity by local calcium microdomains near CRAC channels in human T cells
- Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling 1
- The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
- Calcium oscillations increase the efficiency and specificity of gene expression
- CD28/B7 costimulation: a review.
- STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
- ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation
- Tuning immune responses: diversity and adaptation of the immunological synapse
- Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2*
- Uptake of extracellular Ca2+ and not recruitment from internal stores is essential for T lymphocyte proliferation
- Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.
- Orai1 and STIM Reconstitute Store-operated Calcium Channel Function*
- Apparent cytosolic calcium gradients in T-lymphocytes due to fura-2 accumulation in mitochondria.
- Lymphocyte calcium signaling from membrane to nucleus
- Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
Cited by
- TWIK-related Acid-sensitive K+ Channel 1 (TASK1) and TASK3 Critically Influence T Lymphocyte Effector Functions*
- The role of phosphatidylinositol 3-kinase in P2X7R gated signalling in T lymphocytes
- Vti1b-dependent interaction between lytic granules and recycling TCR compartments is required for efficient function of cytotoxic T lymphocytes
- Immunosuppressive Drugs and Immune Regulation in Organ Transplantation
- Characterization of NPRC and its binding partners
- Mitochondria Positioning Controls Local Calcium Influx in T Cells
- Chloroquine Inhibits Ca2+ Signaling in Murine CD4+ Thymocytes
- Regulatory mechanisms of the calcium selective ion channels TRPV6 and ORAI1
- Mitochondrienlokalisation und Kalziumsignale nach Bildung der Immunologischen Synapse
- SNARE protein expression and localization in human cytotoxic T lymphocytes
- The calcineurin inhibitor tacrolimus allows the induction of functional CD4+CD25+ regulatory T cells by rabbit anti‐thymocyte globulins
- Efficiency of T‐cell costimulation by CD80 and CD86 cross‐linking correlates with calcium entry
- Influence of extracellular magnesium on phagocytosis and free cytosolic Mg levels in differentiated U937 and MH-S cells.
- Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.
- Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death.
- Nonsteroidal Anti-inflammatory Drugs Inhibit Vascular Smooth Muscle Cell Proliferation by Enabling the Ca2+-dependent Inactivation of Calcium Release-activated Calcium/Orai Channels Normally Prevented by Mitochondria*
- TNF-alpha inhibits the CD3-mediated upregulation of voltage-gated K+ channel (Kv1.3) in human T cells.
- Mitochondrial shape changes: orchestrating cell pathophysiology
- The immunological synapse controls local and global calcium signals in T lymphocytes
- Morphological changes of T cells following formation of the immunological synapse modulate intracellular calcium signals.
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