Three-dimensional segregation of supramolecular activation clusters in T cells
Explore this paper's citation graph
Summary
The three-dimensional distribution of receptors and intracellular proteins that cluster at the contacts between T cells and APCs during antigen-specific interactions, Surprisingly, instead of showing uniform oligomerization, these proteins clustered into segregated three- dimensional domains within the cell contacts.
- Type
- article
- Published
- 1998-09-03
- Cited by
- 2,588
- References
- 41
- OpenAlex
- https://openalex.org/W1562441478
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4319319
Keywords
Cell biology, Antigen, Chemistry, Receptor, Antigen-presenting cell
References
- Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR.
- The remodeling of synaptic extracellular matrix and its dynamic relationship with nerve terminals at living frog neuromuscular junctions
- Repeated in vivo visualization of neuromuscular junctions in adult mouse lateral gastrocnemius
- Metamorphosis of the central nervous system of Drosophila.
- T cell antigen-receptor signal transduction.
- Signaling through scaffold, anchoring, and adaptor proteins.
- Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal
- Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.
- The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch
- Selective modulation of protein kinase C-Θ during T-cell activation
- The specific direct interaction of helper T cells and antigen-presenting B cells.
- Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy.
- Heterochronic genes and the temporal control of C. elegans development.
- Green fluorescent protein as a marker for gene expression.
- SH2/SH3 signaling proteins.
- Wavelength mutations and posttranslational autoxidation of green fluorescent protein.
- Changes in the dendritic branching of adult mammalian neurones revealed by repeated imaging in situ
- Experimentally induced alteration in the polarity of developing neurons
- Heterochronic mutants of the nematode Caenorhabditis elegans.
- Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
Cited by
- Effect of aging on T lymphocyte activation.
- Functional Uncoupling of T-cell Receptor Engagement and Lck Activation in Anergic Human Thymic CD4+T Cells*
- Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors.
- A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions
- Live imaging of dendritic cell-Treg cell interactions.
- Cutting Edge: Dependence of TCR Antagonism on Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Activity1
- LFA-1 Integrin beta2 Chain Phosphorylation Regulates Protein Interactions and Mediates Signals in T Cells
- Activated natural killer cells adhere to cultured hippocampal neurons and affect the dendritic morphology.
- Regulating secretory lysosomes.
- Signaling mechanisms utilized by antigen receptors and integrins: common intermediates, different outcomes?
- CXCR3‐mediated T‐cell chemotaxis involves ZAP‐70 and is regulated by signalling through the T‐cell receptor
- Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.
- Spinophilin and the immune synapse
- MTOC translocation modulates IS formation and controls sustained T cell signaling
- The immunological synapse, TCR microclusters, and T cell activation.
- Structure-function effects of mutations in domains of Inducible Tyrosine Kinase
- T-Cell Receptor Microclusters Critical for T-Cell Activation Are Formed Independently of Lipid Raft Clustering
- Early T‐cell activation biophysics
- Modeling of B cell Synapse Formation by Monte Carlo Simulation Shows That Directed Transport of Receptor Molecules Is a Potential Formation Mechanism
- Mechanical Interactions between Dendritic Cells and T Cells Correlate with T Cell Responsiveness
Related papers
- The cytotoxic activity of mouse T lymphocytes against allogeneic cytotoxic T cells.
- The "triggering" of cytotoxic cell differentiation in secondary cultures by subcellular antigens.
- Antigen‐specific suppression of cytotoxic T cell responses in mice. I. Suppressor T cells are not cytotoxic cells
- Differential effects of polyadenylic: polyuridylic acid and lipopolysaccharide on the generation of cytotoxic T lymphocytes
- Cell mediated immune responses in ponies following infection with equine influenza virus (H3N8): the influence of induction culture conditions on the properties of cytotoxic effector cells.
- Coculture with dendritic cells promotes proliferation but not cytotoxic activity of gamma/delta T cells.
- T Cell Response to Embryonal Carcinoma F9 Cells: Induction and Characterization of T Cell Receptor αβ+ Double‐negative Cytotoxic T Lymphocytes
- Effect of nanoparticle surface charge at the plasma membrane and beyond
- Damage of E.coli cell membrane and intracellular enzymic activity induced by pulsed light irradiation