Physiological roles of mitochondrial reactive oxygen species
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Summary
More and more evidence suggests that mROS are critical for healthy cell function, and this evidence is discussed following some background on the generation and regulation of mROS.
- Type
- review
- Published
- 2012-10-26
- Cited by
- 2,515
- References
- 100
- Access
- Open access
- OpenAlex
- https://openalex.org/W2017275974
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40988347
Keywords
Biology, Reactive oxygen species, Mitochondrion, Oxygen, Computational biology
References
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- Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia
- Mitochondria Positioning Controls Local Calcium Influx in T Cells
- Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation.
- SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
- Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
- The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells
- Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense.
- Role of calcium ions in regulation of mammalian intramitochondrial metabolism.
- Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease.
- TLR signaling augments macrophage bactericidal activity through mitochondrial ROS
- Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane*
- A role for mitochondria in NLRP3 inflammasome activation
- Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
- FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
- The NLRP3 Inflammasome Mediates in vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA
- Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.
- Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling
- Coordinated Changes of Mitochondrial Biogenesis and Antioxidant Enzymes During Osteogenic Differentiation of Human Mesenchymal Stem Cells
- Reactive Oxygen Species prime Drosophila haematopoietic progenitors for differentiation
Cited by
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- The ins and outs of the intermembrane space: diverse mechanisms and evolutionary rewiring of mitochondrial protein import routes.
- Rethinking antioxidants in the intensive care unit.
- The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress
- ENOS deficiency causes podocyte injury with mitochondrial abnormality.
- Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells
- Relationship of Mitochondrial Enzymes to Fatigue Intensity in Men With Prostate Cancer Receiving External Beam Radiation Therapy
- Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2
- Toxoplasma gondii Infection Is Associated with Mitochondrial Dysfunction in-Vitro
- Mitochondrial Rieske iron-sulfur protein in pulmonary artery smooth muscle: A key primary signaling molecule in pulmonary hypertension.
- A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2/Non-Type 2 Dichotomy”
- Codonopsis lanceolata attenuates allergic lung inflammation by inhibiting Th2 cell activation and augmenting mitochondrial ROS dismutase (SOD2) expression
- Pro- and antitumor effects of mitochondrial reactive oxygen species
- Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain
- Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease.
- Radiation induced biomarkers of individual sensitivity to radiation therapy
- Subcellular Analysis of the Disulfide Proteome in p66Shc expressing Nerve Cells
- Studies of enzymes in mitochondrial DNA precursor synthesis
- In the eye of the storm: T cell behavior in the inflammatory microenvironment.
- Biomarcadores de la respuesta celular al estrés oxidativo en presencia de antioxidantes en varios modelos celulares
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