Establishing cell-based reporter systems for the analysis of hTERT expression.
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Summary
The hTERT gene, which encodes the catalytic protein subunit of human telomerase, has been shown to be the major determining factor for the expression of telomere length and several small molecule compounds that affect theexpression of telomersase are identified.
- Type
- article
- Published
- 2007-12-01
- Cited by
- 2
- References
- 17
- OpenAlex
- https://openalex.org/W16265602
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22945420
Keywords
Telomerase reverse transcriptase, Telomerase, Telomere, Carcinogenesis, Biology
References
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- Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
- Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?
- Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells.
- Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
- Telomerase: a target for cancer therapeutics.
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