Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.
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Summary
Results indicate that apo A-I has an impaired ability to remove cholesterol and phospholipid from Tangier fibroblasts, possibly because of a defective interaction of apo B-I with cell-surface binding sites.
- Type
- article
- Published
- 1995-07-01
- Cited by
- 425
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2009832539
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21224314
Keywords
Tangier disease, Cholesterol, Apolipoprotein B, ABCA1, Sphingomyelin
References
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- Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells.
- Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting.
- In vivo metabolism of proapolipoprotein A-I in Tangier disease.
- THE INHERITANCE OF HIGH DENSITY LIPOPROTEIN DEFICIENCY (TANGIER DISEASE).
- Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol.
- Cholesterol efflux from arterial wall cells
- Homozygous Tangier disease and cardiovascular disease.
- The high density lipoprotein- and apolipoprotein A-I-induced mobilization of cellular cholesterol is impaired in fibroblasts from Tangier disease subjects.
- Assay of inorganic and organic phosphorus in the 0.1-5 nanomole range.
- Tangier disease: a disorder of intracellular membrane traffic.
- Tangier Disease: Combined Clinical Staff Conference at the National Institutes of Health
- Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion: proposal of a putative model for the pre-beta high-density lipoprotein pathway.
- Abnormal processing of Golgi elements and lysosomes in Tangier disease.
- Dysregulation of lipid metabolism in Tangier monocyte-derived macrophages.
- Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol.
Cited by
- Decreased cholesterol efflux from fibroblasts of a patient without Tangier disease, but with markedly reduced high density lipoprotein cholesterol levels.
- Signal transduction by HDL: agonists, receptors, and signaling cascades.
- Signal transduction pathways provide opportunities to enhance HDL and apoAI-dependent reverse cholesterol transport.
- Expanding roles of ABCG1 and sterol transport
- Methods for Monitoring ABCA1-Dependent Sterol Release
- Understanding the molecular mechanisms behind lipid homeostasis: the role of apoE and hepatic ACAT 2 in atherogenesis
- Development and evaluation of multiplex and high-throughput SNP analysis for the ABCA1 gene
- ENDOGENOUS AND EXOGENOUS SOURCES OF CHOLESTEROL DURING FETAL DEVELOPMENT
- REGULATION OF ATP BINDING CASSETTE TRANSPORTER A1 AND G1 EXPRESSION BY FATTY ACIDS
- Modeling cholesterol in humans: update and dealing with the problem of exchange in vivo using the blood cell-lipoprotein paradigm.
- Amino acids in oral drug delivery:salts, ion-pairs and transcriptomics
- HDL-cholesterol: is it really good? Differences between apoA-I and HDL.
- Régulation du métabolisme et du transport des lipides dans les macrophages : potentiel anti-athérosclérotique des ligands du CD36
- Induction of ABCA1 expression is correlated with increased CREB phosphorylation and altered cytokine secretion
- Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol
- Surface density-induced pleating of a lipid monolayer drives nascent high density lipoprotein assembly
- PPAR-α effects on the heart and other vascular tissues
- Modifying Apolipoprotein A-I by Malondialdehyde, but Not by an Array of Other Reactive Carbonyls, Blocks Cholesterol Efflux by the ABCA1 Pathway*
- CARRIER MEDIATED LIPID TRANSPORT
- Defining an Intracellular Role of Hepatic Lipase in the Formation of Very Low Density Lipoproteins and High Density Lipoproteins
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