Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry.

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Summary

Comprehensive screening of glycation adducts revealed the relative and quantitative importance of alpha-oxoaldehyde-derived advanced glycation endproducts in physiological modification of proteins-particularly hydroimidazolones, the efficient renal clearance of freeAdducts, and the marked increases in glycationadducts in diabetes and uraemia.

Type
article
Published
2003-11-01
Cited by
652
References
40
Access
Open access

Keywords

Glycation, Chemistry, Lysine, Biochemistry, Pentosidine

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