Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
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Summary
A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
- Type
- article
- Published
- 2001-03-01
- Cited by
- 3,056
- References
- 51
- OpenAlex
- https://openalex.org/W1509466986
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4334447
Keywords
Heterochromatin protein 1, Histone H3, Heterochromatin, EZH2, Chromodomain
References
- Functional analysis of the chromo domain of HP1.
- Chromatin : a practical approach
- Epigenetic mechanisms of gene regulation
- Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe
- Heterochromatin protein 1 binds to nucleosomes and DNA in vitro.
- Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner
- Structure and ligand of a histone acetyltransferase bromodomain
- The mouse has a Polycomb-like chromobox gene.
- Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.
- Unfolding the mysteries of heterochromatin.
- Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.
- Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.
- Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin.
- Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes.
- The HP1 protein family: getting a grip on chromatin.
- Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast.
- Initiation of Human DNA Replication in Vitro Using Nuclei from Cells Arrested at an Initiation-competent State*
- The language of covalent histone modifications
- Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation*
- The CBP co-activator is a histone acetyltransferase
Cited by
- Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cells
- Establishment and maintenance of DNA methylation patterns in mammals.
- Imprinted Facultative Heterochromatization in Mealybugs
- Interactions of transcription factors with chromatin.
- Histone modifications in transcriptional regulation.
- Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation
- Selective interaction between the chromatin‐remodeling factor BRG1 and the heterochromatin‐associated protein HP1α
- Interaction of the chromatin compaction‐inducing domain (LR domain) of Ki‐67 antigen with HP1 proteins
- Balance between Acetylation and Methylation of Histone H3 Lysine 9 on the E2F-Responsive Dihydrofolate Reductase Promoter
- Epigenetic reprogramming in mammalian nuclear transfer.
- Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
- Organization of cell–regulatory systems through modular–protein–interaction domains
- Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation.
- Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing
- Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27.
- Acetyllysine-binding and function of bromodomain-containing proteins in chromatin.
- Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location.
- How cells dedifferentiate: a lesson from plants.
- Chromatin higher order structure: opening up chromatin for transcription.
- Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
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