Differential expression of angiopoietin‐1 and angiopoietin‐2 in colon carcinoma
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Summary
The authors hypothesized that the imbalance of Ang‐1 and Ang-2 activities in colon carcinoma leads to a net gain in Ang‐2 function.
- Type
- article
- Published
- 2001-09-01
- Cited by
- 126
- References
- 17
- Access
- Open access
- OpenAlex
- https://openalex.org/W1498167302
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34677043
Keywords
Angiopoietin, Epithelium, Carcinoma, Pathology, Angiogenesis
References
- Angiopoietin‐1 is an apoptosis survival factor for endothelial cells
- Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.
- Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.
- Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2*
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
- Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
- Increased vascularization in mice overexpressing angiopoietin-1.
- In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.
- Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer.
- Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
- Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis.
- Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.
- Vascular endothelial growth factor and the angiopoietins: working together to build a better blood vessel.
- Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
- Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
- Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.
Cited by
- Significance of serum CA125 and TPS antigen levels for determination of overall survival after three chemotherapy courses in ovarian cancer patients during long-term follow-up.
- Angiopoietins and their role in colon cancer angiogenesis.
- Randomised controlled trial of the effects of fish oil emulsion in total parenteral nutrition upon tumour vascularity in patients with hepatic colorectal metastases
- Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors.
- Pathobiology of colorectal cancer hepatic metastases with an emphasis on prognostic factors
- Combination therapy studies with the vascular disruptive agentcombretastatin-a4-phosphate (CA4P)
- Angiopoietin/Tie2 signaling, tumor angiogenesis and inflammatory diseases.
- Plasma concentrations of angiopoietin-1, angiopoietin-2 and Tie-2 in colon cancer.
- Novel radioimmunotherapy for lymphoma and solid tumours both as a single agent and in combination with the vascular disrupting agents
- Alteration of gene expression in rat colon mucosa after exercise.
- The role of the Angiopoietins in vascular morphogenesis
- Biosensing platform combining label-free and labelled analysis using Bloch surface waves
- Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2
- Angiogenesis and its role in colorectal tumor and metastasis formation.
- Prognostic significance of vessel architecture and vascular stability in non-small cell lung cancer.
- Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors.
- Expression of Angiopoietin-2 gene in non-small cell lung cancer
- Neoangiogenesis in human astrocytomas: expression and functional role of angiopoietins and their cognate receptors.
- Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer
- Inhibition of Angiopoietin-2 in LuCaP 23.1 Prostate Cancer Tumors Decreases Tumor Growth and Viability
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