8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage.
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Summary
Methods for DNA isolation continue to improve, with minor modification of the chaotropic NaI technique producing the lowest oxo 8 dG values reported to date using HPLC-EC.
- Type
- review
- Published
- 1999-01-01
- Cited by
- 208
- References
- 16
- OpenAlex
- https://openalex.org/W1497182482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27103169
Keywords
Deoxyguanosine, 8-Hydroxy-2'-deoxyguanosine, Chaotropic agent, DNA, DNA damage
References
- Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection.
- Conditions influencing yield and analysis of 8-hydroxy-2'-deoxyguanosine in oxidatively damaged DNA.
- Oxidative damage to DNA in mammalian chromatin.
- Quantitative high-performance liquid chromatography analysis of DNA oxidized in vitro and in vivo.
- DNA damage and cancer: measurement and mechanism.
- Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue.
- A novel HPLC procedure for the analysis of 8-oxoguanine in DNA.
- Phenol sensitization of DNA to subsequent oxidative damage in 8-hydroxyguanine assays.
- Determination of steady-state levels of oxidative DNA base modifications in mammalian cells by means of repair endonucleases.
- Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis.
- 7,8-Dihydro-8-oxo-2'-deoxyguanosine present in DNA is not simply an artefact of isolation.
- Improvements in the analytical method for 8-hydroxydeoxyguanosine in nuclear DNA.
- Purification of genomic DNA from human whole blood by isopropanol-fractionation with concentrated Nal and SDS.
- Determination of 8-hydroxydeoxyguanosine in human cells under oxygen-free conditions.
- Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997.
- Phenol isolation of DNA yields higher levels of 8-oxodeoxyguanosine compared to pronase E isolation.
Cited by
- Sulindac Enhances the Proteasome Inhibitor Bortezomib-Mediated Oxidative Stress and Anticancer Activity
- Fish Oil Decreases Oxidative DNA Damage by Enhancing Apoptosis in Rat Colon
- Formation of isodialuric acid lesion within DNA oligomers via one-electron oxidation of 5-hydroxyuracil: characterization, stability and excision repair
- Carnosine and N-Acetyl-carnosine Inhibit Salsolinol/Cu,Zn-superoxide Dismutase-mediated DNA Cleavage
- Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells.
- Role of MTH1 and MYH proteins in genotoxic effects of radiation
- Measuring oxidative mtDNA damage and repair using quantitative PCR.
- Oksidatif DNA Hasarı ve Kromatografik Yöntemlerle Tespit Edilmesi
- Oxidation of DNA at guanine by chromium: Products and mechanisms
- Investigation of the antioxidant activity of phenolic compounds in cell culture systems
- Studies on serum 8‐hydroxy guanosine (8‐OHdG) as reliable biomarker for psoriasis
- Effects of oxygen on embryonic stem proliferation, energetics, and differentiation into cardiomyocytes
- Genomic consequences of DNA oxidation by peroxynitrite
- Estrogen receptor regulation of quinone reductase in breast cancer: implications for estrogen-induced breast tumor growth and therapeutic uses of tamoxifen.
- DNA Lesions Caused by ROS and RNOS: A Review of Interactions and Reactions Involving Guanine
- Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.
- The influence of phosphorothioate on charge migration in single and double stranded DNA: a theoretical approach.
- Effect of diet on cancer development: is oxidative DNA damage a biomarker?
- Humic Acid Induces Oxidative DNA Damage, Growth Retardation, and Apoptosis in Human Primary Fibroblasts
- Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors
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