Enhanced levels in neonatal rat liver of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxydeoxyguanosine), a major mutagenic oxidative DNA lesion.
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Summary
Increased formation of this mutagenic DNA lesion during the critical postnatal phase when there is rapid cell proliferation in all tissues is proposed to contribute to carcinogenesis in susceptible tissues later in life.
- Type
- article
- Published
- 1997-07-01
- Cited by
- 34
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988345412
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24634253
Keywords
Deoxyguanosine, DNA oxidation, Carcinogenesis, Oxidative stress, Lesion
References
- 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.
- Reactive oxygen species in tumorigenesis.
- Role of oxygen free radicals in carcinogenesis and brain ischemia
- Organ-specific oxidative DNA damage associated with normal birth in rats.
- Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.
- Mutagenic spectrum resulting from DNA damage by oxygen radicals.
- Structural origins of bulky oxidative DNA adducts (type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence.
- Detection and characterization by 32P-postlabelling of DNA adducts induced by a Fenton-type oxygen radical-generating system.
- Bulky adducts detected by 32P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds.
- Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation.
Cited by
- Nucleotide excision repair and its connection with cancer and ageing.
- Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans.
- Birth-related genomic and transcriptional changes in mouse lung. Modulation by transplacental N-acetylcysteine.
- Detection of bulky endogenous oxidative DNA lesions derived from 8,5'-cyclo-2'-deoxyadenosine by 32P-postlabeling assay
- Spermatozoon DNA'sının Hasarına Neden Olan Faktörler, Tamir ve Hasar Tespit Mekanizmaları
- Age-related increases of 8-hydroxy-2'-deoxyguanosine and DNA-protein crosslinks in mouse organs.
- DNA repair in neural cells: basic science and clinical implications.
- Transcription-coupled repair and premature ageing.
- 8-hydroxy-2'-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution.
- Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells.
- Analysis of aromatic DNA adducts and 7,8‐dihydro‐8‐oxo‐ 2′‐deoxyguanosine in lymphocyte DNA from a case–control study of lung cancer involving minority populations
- Measurement of oxidatively generated base damage to nucleic acids in cells: facts and artifacts
- Spontaneous mutation frequency and pattern in Big Blue® mice fed a vitamin E‐supplemented diet
- Oxidative DNA Damage: Biological Significance and Methods of Analysis
- Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
- A Novel Method Using 8-hydroperoxy-2′-deoxyguanosine Formation for Evaluating Antioxidative Potency
- OGG1 mRNA expression and incision activity in rats are higher in foetal tissue than in adult liver tissue while 8-oxo-2'-deoxyguanosine levels are unchanged.
- Hydroxyl radicals and DNA base damage.
- Measurement of oxidatively generated base damage in cellular DNA.
- Age and Organ Dependent Spontaneous Generation of Nuclear 8-Hydroxydeoxyguanosine in Male Fischer 344 Rats
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