Humic Acid Induces Oxidative DNA Damage, Growth Retardation, and Apoptosis in Human Primary Fibroblasts
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Summary
It is demonstrated that HA adversely affects the growth properties of fibroblasts, one of the key players in wound repair, and initiates oxidative damages to fibro Blasts, and leads to their dwindling growth potential and survival.
- Type
- article
- Published
- 2003-04-01
- Cited by
- 60
- References
- 91
- OpenAlex
- https://openalex.org/W1817255761
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33861160
Keywords
Apoptosis, Reactive oxygen species, Oxidative stress, DNA damage, Fibroblast
References
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- Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.
- Humic substances, a possible source of environmental goitrogens
- Goiter prevalence and bacterial contamination of water supplies.
- p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
- Peripheral vasculopathy in rats induced by humic acids
- The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself.
- A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
- Tissue distribution of absorbed humic acids
- The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.
- Blackfoot disease: arsenic or humic acid?
Cited by
- Evaluating the efficacy, safety and possible mechanism of action of potassium humate with selenium
- Low oxygen tension alleviates oxidative damage and delays cellular senescence in G6PD-deficient cells
- An efficient approach to the quantitative analysis of humic acid in water.
- Humic Substances: Structure, Function, Effects and Applications
- Study of the Removal of Humic Acid, Organic Pollutant by Water Hyacinth Plant from Aquatic Environment and Its Effect on pH, Chlorophyll Content and Degradation
- Lung emphysema induced by cigarette smoke: Studies in mice
- Environmentally relevant concentration of arsenic trioxide and humic acid promoted tumor progression of human cervical cancer cells: In vivo and in vitro studies
- Mechanism of the toxicity induced by natural humic acid on human vascular endothelial cells
- Inhibitory Effect of Fulvic Acid Extracted from Canadian Sphagnum Peat on Chemical Mediator Release by RBL-2H3 and KU812 Cells
- Neuroprotective Effect of Humic Acid on Focal Cerebral Ischemia Injury: an Experimental Study in Rats
- Promoting neoplastic transformation of humic acid in mouse epidermal JB6 Cl41 cells.
- Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis.
- Effects of humic acids in vitro
- Characterization of humic substances of different origin by means of mass spectrometry and neural networks.
- Humic acid enhances the cytotoxic effects of arsenic trioxide on human cervical cancer cells.
- Association of coronary artery calcification with MDA-LDL-C/LDL-C and urinary 8-isoprostane in Japanese patients with type 2 diabetes.
- Removal of dissolved humic acid from water by coagulation method using polyaluminum chloride (PAC) with calcium carbonate as neutralizer and coagulant aid
- Hazardous components and health effects of atmospheric aerosol particles: reactive oxygen species, soot, polycyclic aromatic compounds and allergenic proteins
- Glucose-6-phosphate dehydrogenase-deficient cells show an increased propensity for oxidant-induced senescence.
- Humic acid enhances cigarette smoke-induced lung emphysema in mice and IL-8 release of human monocytes.
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