HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
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Summary
HMK1 provides an example of a cell type‐specific input into the SAPK/JNK pathway and suggests a potential role in hematopoietic lineage decisions and growth regulation.
- Type
- article
- Published
- 1996-12-01
- Cited by
- 257
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W161910285
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20212402
Keywords
Biology, Cell biology, MAP kinase kinase kinase, Haematopoiesis, Protein kinase A
References
- Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15
- MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
- Representative in Vitro cDNA Amplification From Individual Hemopoietic Cells and Colonies
- Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.
- Construction of cDNA libraries from single cells.
- A novel target cell for c‐fos‐induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.
- Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.
- Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center.
- Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
- Activation of MEK‐1 and SEK‐1 by Tpl‐2 proto‐oncoprotein, a novel MAP kinase kinase kinase.
- Murine B cell leukemia line with inducible surface immunoglobulin expression.
- Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions.
- A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content.
- Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
- MAP kinase pathways in yeast: for mating and more.
- Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
- Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells.
- Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.
- Cytokine signaling through nonreceptor protein tyrosine kinases.
- c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine (*)
Cited by
- Activation of Stress-activated Protein Kinase/c-Jun N-terminal Kinase, but Not NF-κB, by the Tumor Necrosis Factor (TNF) Receptor 1 through a TNF Receptor-associated Factor 2- and Germinal Center Kinase Related-dependent Pathway*
- Signal transduction through MAP kinase cascades.
- Src Homology Region 2 Domain-Containing Phosphatase 1 Positively Regulates B Cell Receptor-Induced Apoptosis by Modulating Association of B Cell Linker Protein with Nck and Activation of c-Jun NH2-Terminal Kinase1
- Molecular and cellular mechanisms of T lymphocyte apoptosis.
- Molecular cloning and characterization of a novel human STE20-like kinase, hSLK.
- MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
- The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.
- Activation of hematopoietic progenitor kinase-1 by erythropoietin.
- Primary T cell immunodeficiencies associated with disturbed proximal T cell receptor signalling caused by human autosomal recessive LCK, ZAP-70 and ITK-mutations
- Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family.
- CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms.
- Bidirectional communication between tissues regulating morphogenesis in a Drosophila model of wound healing
- THE ROLE OF ADAPTOR PROTEIN GADS IN CD8+ T CELL-MEDIATED IMMUNITY
- Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
- THE ROLE OF RECEPTOR TYROSINE KINASE AXL IN PANCREATIC DUCTAL ADENOCARCINOMA AND ITS REGULATION BY HEMATOPOIETIC PROGENITOR KINASE 1
- Regulation and Function of Stress-Activated Protein Kinase Signal Transduction Pathways: A Dissertation
- Hematopoietic Progenitor Kinase 1 Is a Negative Regulator of Dendritic Cell Activation
- MAP kinase activation in macrophages
- Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation.
- p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
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