Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
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Summary
Current knowledge about the mixed lineage kinases is summarized and it is suggested that MLKs are not only expressed in cells of the immune system (as well as in the nervous system), but also may be implicated selectively in the signalling pathway that follows on toll‐like receptor ligation in innate sentinel cells, such as the dendritic cell.
- Type
- review
- Published
- 2007-04-01
- Cited by
- 35
- References
- 115
- Access
- Open access
- OpenAlex
- https://openalex.org/W1489137899
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20532558
Keywords
Kinase, Cell biology, Innate immune system, Biology, Autophosphorylation
References
- Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1.
- MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
- CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults
- HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
- A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
- Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.
- Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway
- Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras.
- Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases.
- Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases.
- TLR signalling and the function of dendritic cells.
- TLR2 modulates inflammation in zymosan-induced arthritis in mice
- Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid.
- Toll-like Receptors as Sensors of Pathogens
- A mammalian scaffold complex that selectively mediates MAP kinase activation.
- Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway.
- Inhibition of JNK by Overexpression of the JNK Binding Domain of JIP-1 Prevents Apoptosis in Sympathetic Neurons*
- Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton.
- Mitogen-activated Protein Kinases p38 and ERK 1/2 Mediate the Wall Stress-induced Activation of GATA-4 Binding in Adult Heart*
- Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.
Cited by
- Genetically engineered mouse models in drug discovery research.
- MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes
- Saturated fatty acids induce c-Src clustering within membrane subdomains leading to JNK activation
- CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
- Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
- ZAK negatively regulates RhoGDIβ-induced Rac1-mediated hypertrophic growth and cell migration
- Metabolic stress signaling mediated by mixed-lineage kinases.
- The Functional Analysis of MLKs-JNK Pathways in Osteoclast Formation
- Discovery, Synthesis and Characterization of an Orally Bioavailable, Brain Penetrant Inhibitor of Mixed Lineage Kinase 3
- Rebuilding Synaptic Architecture in HIV-1 Associated Neurocognitive Disease (HAND) – A Therapeutic Strategy Based on Modulation of Mixed Lineage Kinase
- Mixed Lineage Kinase Phosphorylates Transcription Factor E47 and Inhibits TrkB Expression to Link Neuronal Death and Survival Pathways*
- MLK3 Phophorylates AMPK Independently of LKB1
- Adjunctive and Long-Acting Nanoformulated Antiretroviral Therapies for HIV-associated neurocognitive disorders
- HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module.
- MLK3 regulates fMLP-stimulated neutrophil motility
- Cloning and Initial Functional Characterization of Mlk4α and Mlk4β
- Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours
- Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.
- The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions.
- Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway
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