p53 oligomerization and DNA looping are linked with transcriptional activation.
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Summary
Tetramerization and stacking of tetramers provide dual mechanisms to augment the number of p53 molecules available for activation through p53 response elements through protein‐protein interactions.
- Type
- article
- Published
- 1994-12-01
- Cited by
- 131
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W39231010
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36758712
Keywords
Biology, Molecular genetics, Library science, Genetics, Gene
References
No references recorded for this paper.
Cited by
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- Proteasome Inhibitors Enhance TRAIL-Induced Apoptosis through the Intronic Regulation of DR5: Involvement of NF-κB and Reactive Oxygen Species-Mediated p53 Activation1
- A Functional Analysis of the RNA Polymerase II Large Subunit C-Terminal Domain
- Efficiency and versatility of distal multisite transcription regulation
- Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis.
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- The HMG‐box mitochondrial transcription factor xl‐mtTFA binds DNA as a tetramer to activate bidirectional transcription
- Mechanisms of Differential Activation of Target Gene Promoters by p53 Hinge Domain Mutants with Impaired Apoptotic Function*
- Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopy.
- Crystal Structure of the Mouse p53 Core DNA-binding Domain at 2.7 Å Resolution*
- p53 in growth control and neoplasia.
- Control of gene expression by modulated self-assembly
- Oligomerization of p53 upon cooperative DNA binding: towards a structural understanding of p53 function.
- The mouse Ink4a/Arf locus: a p53 pile-up at a tumour surveillance crossroads?
- Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
- Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells.
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