Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?
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Summary
Cancer cells have many degrees of freedom for re-programming cell metabolism, which with better understanding will result in novel therapeutic approaches, and are hence not addicted to glutamine.
- Type
- article
- Published
- 2010-10-01
- Cited by
- 252
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W1986517285
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24719816
Keywords
Glutaminolysis, Glutamine, Biology, Cancer cell, Anaerobic glycolysis
References
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- Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.
- New targets of β-catenin signaling in the liver are involved in the glutamine metabolism
- Cancer cell metabolism: Warburg and beyond.
- Effect of Extracellular AMP on Cell Proliferation and Metabolism of Breast Cancer Cell Lines with High and Low Glycolytic Rates*
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
- A unique glucose-dependent apoptotic pathway induced by c-Myc.
- Changes in the metabolism of glucose, pyruvate, glutamine and glycine during maturation of cattle oocytes in vitro.
- Re-thinking the Warburg Effect with Myc Micro-managing Glutamine Metabolism
- c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism
- Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
- Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells
Cited by
- Emerging concepts in the molecular basis of pulmonary arterial hypertension (PAH): Part I: Metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in PAH
- HNF1β drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)
- Glutaminolysis as a target for cancer therapy
- Altered ovarian cancer metabolism increases neuronal n-acetylaspartate to promote tumor growth
- The roles of translocator protein (TSPO) and adenine nucleotide translocase 2 (ANT2) in breast cancer development and progression
- MTORC1 SIGNALING IN MEMORY FORMATION AND DYSFUNCTION
- Primary liver cancer: Epidemiological and Biomarker Discovery Studies
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
- High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc -) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells
- Overexpression of REG4 confers an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy
- ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation
- Glutamine contributes to maintenance of mouse embryonic stem cell self-renewal through PKC-dependent downregulation of HDAC1 and DNMT1/3a
- Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
- Glutathione in Cancer Cell Death
- The Warburg effect: insights from the past decade.
- miRNAs link metabolic reprogramming to oncogenesis.
- Autophagy in Tumorigenesis and Energy Metabolism: Friend by Day, Foe by Night
- The expression of glutamine-metabolism-related proteins in breast phyllodes tumors
- cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
- Mitochondrial Metabolism Inhibitors for Cancer Therapy
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