Understanding pancreatic cancer genomes
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Summary
Approaches to adjust for low epithelial content in primary tumours and to define the genomic landscape of pancreatic cancer to identify novel candidate driver genes and mechanisms are devised and stratified, molecular phenotype-guided therapeutic strategies are developed.
- Type
- article
- Published
- 2013-08-01
- Cited by
- 40
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W23660961
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5579894
Keywords
DNA methylation, Biology, Oryza sativa, Methylation, Epigenetics
References
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- Update on pancreatic intraepithelial neoplasia.
- Primary results from EMILIA, a phase III study of trastuzumab emtansine (T-DM1) versus capecitabine (X) and lapatinib (L) in HER2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane.
- The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
- Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
- From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets
- Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
- The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma
- Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.
- International network of cancer genome projects
- Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
- ATM mutations in hereditary pancreatic cancer patients
- MuSiC: Identifying mutational significance in cancer genomes
- Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial.
- GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
- Integrated study of copy number states and genotype calls using high-density SNP arrays
- Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
- Cancer statistics, 2012
- qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles
Cited by
- IKAROS and LEUKEMIA
- Diagnostic value of combining CA 19-9 and K-ras gene mutation in pancreatic carcinoma: a meta-analysis.
- Genomic alterations in pancreatic cancer and their relevance to therapy.
- Genomic Profiling Guides the Choice of Molecular Targeted Therapy of Pancreatic Cancer
- Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis.
- Oncogenic KRAS signalling in pancreatic cancer
- Opportunities for translation: targeting DNA repair pathways in pancreatic cancer.
- A historical perspective of pancreatic cancer mouse models.
- High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival
- The complex landscape of pancreatic cancer metabolism.
- Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy
- Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer
- The role of PAK4 in pancreatic cancer
- Individualisierte Therapie beim Pankreaskarzinom
- Advances in Molecular Pathology and Treatment of Periampullary Cancers
- Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines
- Study of Clinical Survival and Gene Expression in a Sample of Pancreatic Ductal Adenocarcinoma by Parsimony Phylogenetic Analysis
- Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?
- Genomics of pancreatic tumours - what we now know
- Diagnostic value of selected markers and apoptotic pathways for pancreatic cancer
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