International network of cancer genome projects
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Summary
Systematic studies of more than 25,000 cancer genomes will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
- Type
- article
- Published
- 2010-04-15
- Cited by
- 2,240
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W2121906867
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:589598
Keywords
Genome, Cancer, Biology, Computational biology, Genomics
References
- Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies.
- Wellcome funds cancer database
- Benefits and Best Practices of Rapid Pre-Publication Data Release
- Mapping the cancer genome
- The hallmarks of cancer
- Reactome knowledgebase of human biological pathways and processes
- Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
- Translating insights from the cancer genome into clinical practice
- Patterns of somatic mutation in human cancer genomes
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- The cancer genome
- Mutation of FOXL2 in granulosa-cell tumors of the ovary.
- Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
- The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes.
- A second generation human haplotype map of over 3.1 million SNPs
- dbSNP: the NCBI database of genetic variation
- High Frequency of Mutations of the PIK3CA Gene in Human Cancers
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES
Cited by
- Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes.
- The breast cancer genome - a key for better oncology
- MAPK pathway activation in pilocytic astrocytoma
- Translating metastasis-related biomarkers to the clinic—progress and pitfalls
- Individualized hepatocellular carcinoma risk: the challenges for designing successful chemoprevention strategies.
- Understanding pancreatic cancer genomes
- Clinical and molecular characterization of HER2 amplified-pancreatic cancer
- Deconvolving tumor purity and ploidy by integrating copy number alterations and loss of heterozygosity
- Challenges and opportunities for next-generation sequencing in companion diagnostics
- Genomic landscape of metastatic colorectal cancer
- Generating a focused view of disease ontology cancer terms for pan-cancer data integration and analysis
- Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type
- Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types
- Single‐cell profiling approaches to probing tumor heterogeneity
- Findings made in gene panel to whole genome sequencing: data, knowledge, ethics – and consequences?
- A practical approach to liver metastasis from unknown primary cancer: What surgeons need to know.
- Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis
- The rise of genomic profiling in ovarian cancer
- Impact of Nonsynonymous Single-Nucleotide Variations on Post-Translational Modification Sites in Human Proteins.
- Selective identification of somatic mutations in pancreatic cancer cells through a combination of next-generation sequencing of plasma DNA using molecular barcodes and a bioinformatic variant filter
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