Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
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Summary
It is found that pancreatic cancers contain an average of 63 genetic alterations, the majority of which are point mutations, which defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67 to 100% of the tumors.
- Type
- article
- Published
- 2008-09-04
- Cited by
- 4,034
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2138155367
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2163181
Keywords
Biology, Carcinogenesis, Pancreatic cancer, Transcriptome, Gene
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- Human variation databases
- Mutational Profiling of Kinases in Human Tumours of Pancreatic Origin Identifies Candidate Cancer Genes in Ductal and Ampulla of Vater Carcinomas
- The origins of cancer robustness and evolvability.
- The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting
- New Developments in Pancreatic Cancer
- Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes.
- Global microRNA expression profiling of microdissected tissues identifies miR‐135b as a novel biomarker for pancreatic ductal adenocarcinoma
- Personalized therapy for pancreatic cancer: Myth or reality in 2010?
- Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.
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- Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases.
- APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival
- Identification and characterization of alternative exon usage linked glioblastoma multiforme survival
- Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers
- The effect of one additional driver mutation on tumor progression
- Understanding pancreatic cancer genomes
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