Endoplasmic Reticulum Stress in Hearing Loss
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Summary
Animal experiments showed that chemical chaperones or ER stress inducers alleviate environment-related hearing loss, whereas ER stress inhibitor has been used to treat certain types of hereditary deafness.
- Type
- article
- Published
- 2017-11-01
- Cited by
- 4
- References
- 112
- Access
- Open access
- OpenAlex
- https://openalex.org/W2766222389
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:90865984
Keywords
Unfolded protein response, Endoplasmic reticulum, Hearing loss, Cell biology, Secretion
References
- Mutation analysis of the WFS1 gene in seven Danish Wolfram syndrome families; four new mutations identified
- Signal integration in the endoplasmic reticulum unfolded protein response
- Impaired unfolded protein response in the degeneration of cochlea cells in a mouse model of age-related hearing loss.
- XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death
- Connexin 26 gene linked to a dominant deafness
- ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment
- Age-related hearing impairment and the triad of acquired hearing loss
- Neuronal ER Stress in Axon Injury and Neurodegeneration
- Disease-causing mutations in the CLRN1 gene alter normal CLRN1 protein trafficking to the plasma membrane
- The WFS1 gene, responsible for low frequency sensorineural hearing loss and Wolfram syndrome, is expressed in a variety of inner ear cells
- Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus
- Neuroprotective effects of cutamesine, a ligand of the sigma‐1 receptor chaperone, against noise‐induced hearing loss
- Mutations in the WFS1 gene that cause low-frequency sensorineural hearing loss are small non-inactivating mutations
- XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
- Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene
- Usher syndrome: definition and estimate of prevalence from two high-risk populations.
- Identification of Mutations in Members of the Connexin Gene Family as a Cause of Nonsyndromic Deafness in Taiwan
- Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways
- XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.
- Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.
Cited by
- Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health
- Do wolframin, P-glycoprotein, and GRP78/BiP cooperate to alter the response of L1210 cells to endoplasmic reticulum stress or drug sensitivity?
- Hidden biochemical action of Ethanol on colon carcinoma cell models
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