The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress*
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Summary
A possible role of the Nrf2-antioxidant response element transcriptional pathway in neuroprotection and the nature of this pathway and the mechanisms by which Keap1 acts to repress NRF2 activity are the topics of discussion in this minireview.
- Type
- article
- Published
- 2009-05-15
- Cited by
- 2,536
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W19182219
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38297071
Keywords
Dairy cattle, Agronomy, Dairy farming, Agricultural science, Business
References
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- An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
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- Assessing the contribution of antiretroviral therapy to neuronal damage and death as a mediator of cognitive decline in HIV-associated neurocognitive disorders
- Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice
- Role of dimethyl fumarate in oxidative stress of multiple sclerosis: A review.
- 3-O-Laurylglyceryl ascorbate activates the intracellular antioxidant system through the contribution of PPAR-γ and Nrf2.
- Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
- Prevalence of exposure of heavy metals and their impact on health consequences
- Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins
- Xueshuantong injection (lyophilized) combined with salvianolate lyophilized injection protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress
- Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain.
- Chemoprotection against cancer by isothiocyanates: a focus on the animal models and the protective mechanisms.
- Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid.
- E-p-Methoxycinnamoyl-α-l-rhamnopyranosyl Ester, a Phenylpropanoid Isolated from Scrophularia buergeriana, Increases Nuclear Factor Erythroid-Derived 2-Related Factor 2 Stability by Inhibiting Ubiquitination in Human Keratinocytes
- APR3 modulates oxidative stress and mitochondrial function in ARPE‐19 cells