Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.
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Summary
It is concluded that Ya gene activation by planar aromatic compounds involves metabolism of these inducers by the phase I xenobiotic-metabolizing cytochrome P1-450 system into electrophilic compounds, which is consistent with a recently proposed model.
- Type
- article
- Published
- 1990-08-01
- Cited by
- 468
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967692811
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38238566
Keywords
Mutant, Biology, Gene expression, Molecular biology, Biochemistry
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