Phenotypic and Functional Analysis of CD4+CD25−Foxp3+ T Cells in Patients with Systemic Lupus Erythematosus1
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Summary
Combined phenotypic and functional analyses of CD4+CD25−Foxp3+ T cells revealed increased proportions in SLE patients as compared with patients with systemic sclerosis, rheumatoid arthritis, (RA), or HC and their selective functional defects might contribute to the failure of Treg to control autoimmune dysregulation in Sle patients.
- Type
- article
- Published
- 2009-02-01
- Cited by
- 180
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W19155519
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20675780
Keywords
Computer science
References
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- CD4+CD25− T Cells in Aged Mice Are Hyporesponsive and Exhibit Suppressive Activity 1
- The quantitative analysis of peripheral blood FOXP3‐expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients
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- Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
- Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.
- Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
- Immune cell signaling defects in lupus: activation, anergy and death.
- Decreased CD4+CD25+ T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus
- B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
- Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.
Cited by
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- Identification of Immunomodulatory Cells Induced By 670 nm Light Therapy in an Animal Model of Multiple Sclerosis
- Importance of TGF-beta Signaling in Dendritic Cells to Maintain Immune Tolerance
- The Percentage of FoxP3+Helios+ Treg Cells Correlates Positively With Disease Activity in Systemic Lupus Erythematosus
- Imbalance of different types of CD4+forkhead box protein 3 (FoxP3)+ T cells in patients with new‐onset systemic lupus erythematosus
- Immunoendocrine Interactions during HIV-TB Coinfection: Implications for the Design of New Adjuvant Therapies
- Altered frequency and phenotype of CD4+ forkhead box protein 3+ T cells and its association with autoantibody production in human immunodeficiency virus‐infected paediatric patients
- T regulatory cells in B‐cell malignancy – tumour support or kiss of death?
- CD4+CD25−Foxp3+ T cells play a role in tuberculous hydrothorax rather than malignant hydrothorax
- Regulatory T cells in systemic lupus erythematosus
- Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis
- Phenotypic alterations of regulatory T cells in autoimmune hepatitis: Causal or associated with treatment and remission?
- Aberrant expression of regulatory cytokine IL-35 in patients with systemic lupus erythematosus
- Regulatory T cells in systemic lupus erythematosus (SLE); role of peptide tolerance.
- The Impact of Aging on Regulatory T-Cells
- Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells
- Imbalance of Different Types of CD4+Foxp3+ T cells in renal transplant recipients
- T –cell specific defect in expression of the NTPDase CD39 as a biomarker for lupus
- Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension
- CD4+CD25-Foxp3+ T cells: a marker for lupus nephritis?
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