Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
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Summary
Naturally arising CD25+CD4+ regulatory T cells actively maintain immunological self-tolerance, and are a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.
- Type
- review
- Published
- 2005-04-01
- Cited by
- 2,918
- References
- 113
- OpenAlex
- https://openalex.org/W2004708987
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14683763
Keywords
FOXP3, Self Tolerance, IL-2 receptor, Immunology, Immune tolerance
References
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- Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
- A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
- QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2
- Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
- Large scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells
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- Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells1
- Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression 1
- The effect of infections on susceptibility to autoimmune and allergic diseases.
Cited by
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- Live imaging of dendritic cell-Treg cell interactions.
- Clinical significance of T-regulatory cells in B-cell non-Hodgkin's lymphoma.
- A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
- Tumor immunology, immunomics and targeted immunotherapy for central nervous system malignancies
- Immunopathogenesis of psoriasis: recent insights on the role of adaptive and innate immunity.
- Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
- Inhibitory effects of B cells on antitumor immunity.
- Dendritic cells expand antigen‐specific Foxp3+CD25+CD4+ regulatory T cells including suppressors of alloreactivity
- Immune privilege in sites of chronic infection: Leishmania and regulatory T cells
- Skin controls immune regulators
- A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses.
- Limited Peripheral T Cell Anergy Predisposes to Retinal Autoimmunity1
- Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells
- The Effects of Immunosuppression on Regulatory CD4+CD25+ T Cells
- Phenotypic and Functional Analysis of CD4+CD25−Foxp3+ T Cells in Patients with Systemic Lupus Erythematosus1
- Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-beta.
- Regulatory T cells and viral liver disease
- New directions for induction immunosuppression strategy in solid organ transplantation.
- Programmed Death-1 antibody blocks therapeutic effects of T-regulatory cells in cockroach antigen-induced allergic asthma.
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