Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-α in patients with recent-onset type 1 diabetes
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Summary
Macrophages and dendritic cells infiltrate the islets and produce inflammatory cytokines (TNF-α and IL-1β) during the development of type 1A diabetes.
- Type
- article
- Published
- 2007-01-13
- Cited by
- 125
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W17221211
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2715126
Keywords
Computer science
References
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- Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.
- Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.
- Pancreatic beta-cell destruction in non-obese diabetic mice.
- Treatment With Neutralizing Antibodies Specific for IL-1β Prevents Cyclophosphamide-Induced Diabetes in Nonobese Diabetic Mice
- Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
- Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2
- Examination of islets in the pancreas biopsy specimens from newly diagnosed Type 1 (insulin-dependent) diabetic patients
- IL-1 receptor deficiency slows progression to diabetes in the NOD mouse.
- IL‐1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non‐obese diabetic (NOD) mice
- Evidence that beta cell death in the nonobese diabetic mouse is Fas independent.
- Dominant TCR alpha-chain clonotypes and interferon-gamma are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus.
- Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation
- Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
- Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity.
- TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.
- Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus
- Type I diabetes mellitus: a chronic autoimmune disease?
Cited by
- The role for endoplasmic reticulum stress in diabetes mellitus.
- Altered toll-like receptor signaling pathways in human type 1 diabetes
- In vitro cytokine profiles and viability of different human cells treated with whole cell lysate of Mycobacterium avium subsp. paratuberculosis
- Bipolar Role for Myelo-Monocytic Cells in Autoimmune Diseases and Psychiatric Disorders
- Histopathology of type 1 diabetes: old paradigms and new insights.
- Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans
- Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis
- A study of biomarker analysis in association with type 1 diabetes and their shared features in rheumatoid arthritis
- Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Pro-Inflammatory Cytokines Inducing Th17 Cells
- Estudio de marcadores genéticos asociados a diabetes tipo 1 en población española con debut pediátrico y adulto
- Mutation analysis of Wolfram syndrome patients and functional study of the wolframin protein
- Interactions between enteroviruses and the host : implications for type 1 diabetes
- GAD65 autoimmunity-clinical studies.
- Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes
- Impaired wound healing in mouse models of diabetes is mediated by TNF-α dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1)
- Sphingomyelinase dependent apoptosis of dendritic cells following treatment with amyloid peptides.
- Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes
- 1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism.
- Cytokine-induced human islet cell death in vitro correlates with a persistently high phosphorylation of STAT-1, but not with NF-κB activation.
- Insulitis in Human Type 1 Diabetes
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