Modeling the cholesteatoma microenvironment: coculture of HaCaT keratinocytes with WS1 fibroblasts induces MMP-2 activation, invasive phenotype, and proteolysis of the extracellular matrix.
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Summary
This simple culture model may help further the understanding of these destructive behaviors in cholesteatoma keratinocytes, including ECM proteolysis, and stromal fibroblasts may stimulate the invasive phenotype of Keratinocytes.
- Type
- article
- Published
- 2007-02-01
- Cited by
- 20
- References
- 25
- OpenAlex
- https://openalex.org/W17204986
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35779083
Keywords
Facade, Roof, Terminal (telecommunication), Structural engineering, Engineering
References
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- Rho GTPases in cell biology
- Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis.
- Inhibition of matrix metalloproteinases in gerbil cholesteatoma: Preliminary findings
- Up-regulation of matrix metalloprotease-9 in middle ear cholesteatoma – correlations with growth factor expression in vivo?
- Etiopathogenesis of cholesteatoma
- Identification of specific gene expression profiles in fibroblasts derived from middle ear cholesteatoma.
- Rac1 Mediates Type I Collagen-dependent MMP-2 Activation
- Possible Involvement of Keratinocyte Growth Factor and Its Receptor in Enhanced Epithelial-Cell Proliferation and Acquired Recurrence of Middle-Ear Cholesteatoma
- Cell-to-cell communication within intact human skin.
- Structural Changes and Protein Expression in the Mastoid Bone Adjacent to Cholesteatoma
Cited by
- Molecular biology of cholesteatoma.
- Laminin‐332 and ‐511 in skin
- Co‑culture with human fetal epidermal keratinocytes promotes proliferation and migration of human fetal and adult dermal fibroblasts.
- Expression of Ras-related C3 botulinum toxin substrate 1 (RAC1) in human cholesteatoma
- Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
- Cholesteatoma Growth and Proliferation: Post-Transcriptional Regulation by microRNA-21
- TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2.
- Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2.
- Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP‐1
- Cholesteatoma gene expression of matrix metalloproteinases and their inhibitors by RT-PCR
- Immune cell profile in invasive cholesteatomas: preliminary findings.
- Prostaglandin E2-mediated migration of human trophoblast requires RAC1 and CDC42.
- EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2.
- Nemosis of fibroblasts is inhibited by benign HaCaT keratinocytes but promoted by malignant HaCaT cells
- RhoGDI2 Is Expressed in Human Trophoblasts and Involved in Their Migration by Inhibiting the Activation of RAC11
- Fibronectin-integrin interaction promotes fibroblast activation (nemosis) and crosstalk with tumor cells
- The Viability and Growth of HaCaT Cells After Exposure to Bioactive Glass S53P4-Containing Cell Culture Media
- Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect
- Benign, persistent, and invasive: mechanistic and translational approaches to middle‑ear cholesteatoma
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