Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP‐1
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Summary
The results indicate that IAX exerts anticancer effect in SW620 cells by targeting MMP‐2 via regulating the activity of Rac1 and AP‐1, and suggest IAX to be a promising antimetastatic agent.
- Type
- article
- Published
- 2009-12-16
- Cited by
- 29
- References
- 49
- OpenAlex
- https://openalex.org/W2013280591
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36056395
Keywords
RHOA, RAC1, Cancer research, Metastasis, CDC42
References
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- Indonesian medicinal plants
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Cited by
- Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-κB signalings in colorectal cancer cells
- Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression
- Gambogic acid-loaded magnetic Fe3O4 nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1
- Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots.
- 1-calcium phosphate-uracil, a synthesized pyrimidine derivative agent, has anti-proliferative, pro-apoptotic and anti-invasion effects on multiple tumor cell lines
- TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2.
- Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2.
- Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes
- Inhibition of azoxymethane-induced preneoplastic lesions in the rat colon by a stearic acid complexed high-amylose cornstarch using different cooking methods and assessing potential gene targets
- Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity.
- Identification of differentially expressed genes and their subpathways in recurrent versus primary bone giant cell tumors.
- Designer Xanthone
- Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway.
- Hormonally active doses of isoflavone aglycones promote mammary and endometrial carcinogenesis and alter the molecular tumor environment in Donryu rats.
- HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5
- Aptamer conjugated theragnostic multifunctional magnetic nanoparticles as a nanoplatform for pancreatic cancer therapy
- Assessing the inhibition of azoxymethane-induced preneoplastic lesions in the rat colon by cooked resistant corn starches and identifying potential genetic targets
- Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation.
- Rhein suppresses matrix metalloproteinase production by regulating the Rac1/ROS/MAPK/AP-1 pathway in human ovarian carcinoma cells.
- Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells.
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