Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders.

Keywords

Amyloid precursor protein secretase, Amyloid precursor protein, Drug discovery, Clathrin, Biology

References

• Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γR. L. McKinney, D.M. Boyd, Atsushi Kuramoto — 2001
• A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions祐子 萩ノ脇, 育野 鈴木, 達夫 野部 — 2002
• Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines*Gaochao Tian, Cynthia D. Sobotka‐Briner, John R. Zysk — 2002
• Effect of tumor necrosis factor‐α converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neuronsMiguel Ángel Zabalza Beraza — 2002
• Modulation of β‐amyloid metabolism by non‐steroidal anti‐inflammatory drugs in neuronal cell culturesTeresa Alarcón Alarcón, Juan Ignacio González-Montalvo — 2003
• Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components*Amadeu Obach — 2005
• Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREBFernando Escalante Gonzalbo — 2006
• GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-PeptideAmador Cabra, Luis Eduardo — 2006
• Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)Weiping Qin, Mark E. Chachich, Mark A. Lane — 2006
• Napsins: new human aspartic proteinasesPeter J. Tatnell, David J. Powell, Jeffrey Hill — 1998
• S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease.Flaubert Tchantchou, Michael V. Graves, Daniela Ortiz — 2006
• Role of Proteases in the Pathophysiology of Neurodegenerative DiseasesÁbel Lajtha, Naren L. Banik — 2002
• Alzheimer's disease : advances in etiology, pathogenesis, and therapeuticsKhalid Iqbal, Sangram S. Sisodia, Bengt Winblad — 2001
• Usefulness of Behavioral and Electrophysiological Studies in Transgenic Models of Alzheimer's DiseaseA. Santangelo, Fabrizio Trinchese, Ottavio Arancio — 2003
• Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1Yue‐Ming Li, Min Xu, Ming‐Tain Lai — 2000
• Membrane Topology of γ-Secretase Component PEN-2*Adam Crystal, Vanessa A. Morais, Theodore C. Pierson — 2003
• Reconstitution of γ-secretase activityDieter Edbauer, Edith Winkler, Jörg T. Regula — 2003
• Regulatory roles of presenilin‐1 and nicastrin in neuronal differentiation during in vitro neurogenesisSaumyendra N. Sarkar, Hriday K. Das — 2003
• Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen‐2) demonstrate excessive p53‐dependent apoptosis and neuronal lossWilliam A. Campbell, Hongwei Yang, Henrik Zetterberg — 2006
• A second cytotoxic proteolytic peptide derived from amyloid β-protein precursorDaniel C. Lu, Shahrooz Rabizadeh, Sreeganga S. Chandra — 2000

Cited by

• A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesisLin Teng, Jian Zhao, Feifei Wang — 2010
• Modulation of APP Expression Reduces Aβ Deposition in a Mouse ModelAyodeji A. Asuni, Maitea Guridi, Joanna Pankiewicz — 2014
• Comparison of Aβ levels in the brain of Swedish APP670, 671 and PS1M146V mutation carriers and patients with sporadic Alzheimer's diseaseEwa Hellström‐Lindahl, Matti Viitanen, Amelia Marutle — 2009
• Immunohistoblot analysis on whole human hemispheres from normal and Alzheimer diseased brains.Zsuzsa Beliczai, Szilvia Várszegi, Balázs Gulyás — 2008
• Expression of STIM1 in brain and puncta-like co-localization of STIM1 and ORAI1 upon depletion of Ca(2+) store in neurons.Monika E. Klejman, Joanna Gruszczynska‐Biegala, Anna Skibinska-Kijek — 2009
• Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivoSariah J. Allen, Kevin R. Mott, Homayon Ghiasi — 2014
• Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer's disease.Ai Fu, Cheng Yu Zhou, Xiang Chen — 2010
• Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptorsShaomin Li, Ming Jin, Thomas Koeglsperger — 2011
• A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates Aβ Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's DiseaseHiroaki Fukumoto, Hideki Takahashi, Naoki Tarui — 2010
• Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease.Magdolna Pákáski, János Kálmán — 2008
• Overactivation of calcineurin induced by amyloid-beta and prion proteins.Paula Agostinho, João Pedro Lopes, Zélia Velez — 2008
• Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease.Giovanna Traina, Giuseppe Federighi, Marcello Brunelli — 2008
• Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulationYoshiari Shimmyo, Takeshi Kihara, Akinori Akaike — 2008
• Efficient four‐drug cocktail therapy targeting amyloid‐β peptide for Alzheimer's diseaseMasashi Asai, Nobuhisa Iwata, Taisuke Tomita — 2010
• Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.Lihong Zhang, Xin Wang, Meredin Stoltenberg — 2008
• Capsaicin promotes the amyloidogenic route of brain amyloid precursor protein processing.Magdolna Pákáski, Marietta Hugyecz, Péter Sántha — 2009
• Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons.Roberta Epis, Elena Marcello, Fabrizio Gardoni — 2008
• The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.Roxana C. Sinjoanu, Sara Kleinschmidt, Robert S. Bitner — 2008
• Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons.Neville Marks, Martin J. Berg, Mariko Saito — 2008
• Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aβ peptide levels and impaired learning behavior in aged rats.Hideki Takahashi, Hiroaki Fukumoto, Ryouta Maeda — 2010

Related papers

• Presenilin 1 Mutations Activate γ42-Secretase but Reciprocally Inhibit ε-Secretase Cleavage of Amyloid Precursor Protein (APP) and S3-Cleavage of Notch*Fusheng Chen, Yongjun Gu, Hiroshi Hasegawa — 2002
• The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10Lisa Hitschler, Thorsten Lang — 2022
• The role of APP and BACE1 trafficking in APP processing and amyloid-β generationXiaojie Zhang, Weihong Song — 2013
• Modulators and inhibitors of gamma- and beta-secretases.Boris Schmidt, Stefanie Baumann, Rajeshwar Narlawar — 2006
• Amyloid‐β protein (Aβ) Glu11 is the major β‐secretase site of β‐site amyloid‐β precursor protein‐cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesisYu Deng, Zhe Wang, Ruitao Wang — 2013
• Cleavage of Alzheimer’s Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory PathwaySusumu Tomita, Yutaka Kirino, Toshiharu Suzuki — 1998
• Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein PrecursorNaohiro Itoh, Masayasu Okochi, Shinji Tagami — 2009
• Secretases Related to Amyloid Precursor Protein ProcessingXiaoling Liu, Yan Liu, Shang‐Rong Ji — 2021
• Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies.Michal Arbel, Iftach Yacoby, Beka Solomon — 2005