Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.

Keywords

Amyloid precursor protein, Biochemistry, Transmembrane domain, Protease, Biology

References

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• Functional Characterization of the Presenilin Homologue SPE-4Aya Yamasaki-Meythaler — 2006
• Presenilin, Notch, and the genesis and treatment of Alzheimer's diseaseW.M.E. Logister, H.H.M. Roebben, L.W.J.M. van der Tuin — 2001
• Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines*Gaochao Tian, Cynthia D. Sobotka‐Briner, John R. Zysk — 2002
• Solution studies and structural model of the extracellular domain of the human amyloid precursor protein.Philip Cheung, A. J. Hayman, Patrick Vessereau — 2002
• BACE1 and Presenilin: Two Unusual Aspartyl Proteases Involved in Alzheimer’s Disease正人 相澤, ヴァレリー マクガウン, 好美 福村 — 2004
• GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-PeptideAmador Cabra, Luis Eduardo — 2006
• Receptor tyrosine kinases positively regulate BACE activity and Amyloid-β production through enhancing BACE internalizationVera Atzorn — 2007
• Therapeutic options in Alzheimer’s diseasePaula I. Moreira, Xiongwei Zhu, Akihiko Nunomura — 2006
• Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.Concepción Palacios Bernal — 2012
• Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.S.L. Forkner, S.R. Specker — 2013
• Assessing the contribution of antiretroviral therapy to neuronal damage and death as a mediator of cognitive decline in HIV-associated neurocognitive disordersPatrick J. Gannon — 2014
• The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation正弥 萩原, 敬未 奥林 — 2015
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer's DiseaseHao Cui — 2012
• Rôle des ADAM dans le processus physiopathologique de la maladie d'AlzheimerGeoffroy Laumet — 2010
• Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.Pauline Pl So, Christina E. Khodr, Ci-Di Chen — 2013
• Disease-Modifying Approach to the Treatment of Alzheimer’s DiseaseFrancesco Panza, Vincenzo Solfrizzi, Vincenza Frisardi — 2009
• Efecto del resveratrol en modelos murinos de envejecimiento y enfermedad de AlzheimerDavid Porquet Costa — 2014
• Notch signaling : From receptor cleavage to chromatin remodelingKia Strömberg — 2005
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