The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells.
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Summary
The authors' results identified the repression activities of EGCG and EGC toward telomerase expression that might be linked to inhibition of carcinoma cell growth.
- Type
- article
- Published
- 2006-05-08
- Cited by
- 52
- References
- 24
- OpenAlex
- https://openalex.org/W1988634132
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32069154
Keywords
Telomerase reverse transcriptase, Telomerase, Psychological repression, Cancer research, Molecular biology
References
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- Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.
- Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines.
- The increase of voltage-gated potassium channel Kv3.4 mRNA expression in oral squamous cell carcinoma.
- Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone.
- Epigallocatechin Gallate, a Constituent of Green Tea, Represses Hepatic Glucose Production*
- Anti‐proliferative and proapoptotic effects of (−)‐epigallocatechin‐3‐gallate on human melanoma: Possible implications for the chemoprevention of melanoma
- Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas.
- Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells
- Chromosome first aid.
- Modulation of KGF-1 gene expression in oral fibroblasts by ripe areca nut extract.
- Inhibition of cyclin‐dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (−)‐epigallocatechin‐3‐gallate
- Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation
- Telomerase as a prognostic marker in breast cancer: high‐throughput tissue microarray analysis of hTERT and hTR
- Regulation of IGFBP‐5 expression during tumourigenesis and differentiation of oral keratinocytes
- Telomerase regulation: not just flipping the switch.
- Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin.
- hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
- Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells.
- Role of telomerase in cell senescence and oncogenesis.
Cited by
- Establishing cell-based reporter systems for the analysis of hTERT expression.
- Molecular and cellular cues of diet-associated oral carcinogenesis--with an emphasis on areca-nut-induced oral cancer development.
- Nutrigenomics and proteomics in health and disease : food factors and gene interactions
- Molecular Characterization of Tea Catechin Treated Human Prostate Cancer Cell Lines
- Increase of ZASC1 gene copy number in recurrent oral carcinoma.
- The effect of β-ionone on telomerase activity in the human leukemia cell line K562
- Therapeutic targeting of replicative immortality
- Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG
- The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin
- Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway.
- Antiproliferative effects of the major tea polyphenol, (-)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma.
- Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non‐small cell lung cancer cells
- Chemopreventive Potential of Green Tea Catechins in Hepatocellular Carcinoma
- Green tea catechins: a fresh flavor to anticancer therapy
- Epigenetic Modifications by Dietary Phytochemicals: Implications for Personalized Nutrition
- Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression
- Chemopreventive and Therapeutic Potential of Tea Polyphenols in Hepatocellular Cancer
- In vitro anti-telomerase activity of novel lycopene-loaded nanospheres in the human leukemia cell line K562
- Common tea formulations modulate in vitro digestive recovery of green tea catechins.
- Complexing of Green Tea Catechins with Food Constituents and Degradation of the Complexes by Lactobacillus plantarum
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