Enterococcus faecalis Glycolipids Modulate Lipoprotein-Content of the Bacterial Cell Membrane and Host Immune Response
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Summary
Evidence is provided that an E. faecalis mutant lacking its major bilayer forming glycolipid DGlcDAG upregulates lipoprotein expression leading to increased activation of the host innate immune system and virulence in vivo.
- Type
- article
- Published
- 2015-07-14
- Cited by
- 13
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W1847117303
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:550763
Keywords
Enterococcus faecalis, Glycolipid, TLR2, Microbiology, Biology
References
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- Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality
- Repression of Bacterial Lipoprotein Production by F. novicida Facilitates Evasion of Innate Immune Recognition
- Isolation and Chemical Characterization of a Capsular Polysaccharide Antigen Shared by Clinical Isolates ofEnterococcus faecalis and Vancomycin-ResistantEnterococcus faecium
- Dual Role of TLR2 and Myeloid Differentiation Factor 88 in a Mouse Model of Invasive Group B Streptococcal Disease 1
- Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins
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- Heterogeneity of Host TLR2 Stimulation by Staphylocoocus aureus Isolates
- The prolipoprotein diacylglyceryl transferase (Lgt) of Enterococcus faecalis contributes to virulence.
- Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.
- Structural Features of Glycosyltransferases Synthesizing Major Bilayer and Nonbilayer-prone Membrane Lipids inAcholeplasma laidlawii and Streptococcus pneumoniae * 210
- A quantitative analysis software tool for mass spectrometry–based proteomics
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- Deletion of the glycosyltransferase bgsB of Enterococcus faecalis leads to a complete loss of glycolipids from the cell membrane and to impaired biofilm formation
- Altered lipid composition in Streptococcus pneumoniae cpoA mutants
Cited by
- Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines
- Mycobacterium tuberculosis lipoproteins in virulence and immunity – fighting with a double‐edged sword
- Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model
- Model systems for the study of Enterococcal colonization and infection
- Bacterial lipids: powerful modifiers of the innate immune response
- Stereoselective Synthesis of Diglycosyl Diacylglycerols with Glycosyl Donors Bearing a β-Stereodirecting 2,3-Naphthalenedimethyl Protecting Group.
- Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress
- Loss of LafB activity reverses daptomycin resistance in E. faecium
- Virulence Profiling of Multidrug-Resistant Clinical Staphylococcus aureus Isolates
- Title Model systems for the study of Enterococcal colonizationand infection
- Correction: Enterococcus faecalis Glycolipids Modulate Lipoprotein-Content of the Bacterial Cell Membrane and Host Immune Response
- In silico designing of a novel multiple epitope vaccine against vancomycin resistant Enterococcus faecalis; An immunoinformatic-guided approach
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