Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Summary
It is shown that Tax can perturb Smad-dependent TGF-beta signaling even though no direct interaction of Tax and Smad proteins could be detected, suggesting that the CBP/p300 binding domain of Tax is essential for the suppression of Smad function.
- Type
- article
- Published
- 2001-04-01
- Cited by
- 101
- References
- 82
- OpenAlex
- https://openalex.org/W11264182
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23449004
Keywords
Political science, Economics
References
- Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
- Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation.
- Expression of human inducible nitric oxide synthase gene in T-cell lines infected with human T-cell leukemia virus type-I and primary adult T-cell leukemia cells.
- Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription.
- Mechanism of activation of the TGF-β receptor
- Smad4 and FAST-1 in the assembly of activin-responsive factor
- The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3
- Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B.
- Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a
- Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.
- Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways
- TGF-β signalling from cell membrane to nucleus through SMAD proteins
- Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein
- Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region
- The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells
- Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation
- Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter
- Role of p300, a transcriptional coactivator, in signalling of TGF‐β
- CREB-binding Protein Is a Nuclear Integrator of Nuclear Factor-κB and p53 Signaling*
- A transforming growth factor beta type I receptor that signals to activate gene expression.
Cited by
- Transforming growth factor-β signaling in normal and malignant hematopoiesis
- Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
- iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns
- Induction of Human T Cell Leukemia Virus Type I Receptors on Quiescent Naive T Lymphocytes by TGF-β12
- TGF-β signaling in tumor suppression and cancer progression
- Seizing of T cells by human T-cell leukemia/lymphoma virus type 1.
- Targeting of the Myc pathway as a novel approach for cancer therapy
- Role of transforming growth factor-beta in hematologic malignancies.
- Induction by transforming growth factor-β1 of epithelial to mesenchymal transition is a rare event in vitro
- Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc.
- Telomerase Regulation and Telomere Maintenance during Human T-cell Leukemia/Lymphoma Virus (HTLV-I) Transformation
- Human T cell leukemia virus type 1: the role of Tax in leukemogenesis.
- Transforming growth factor-β in cancer and metastasis
- Regulation of cell proliferation by Smad proteins
- KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor.
- Leukemogenesis of Adult T-Cell Leukemia
- Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells.
- Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice
- Host soluble factors that regulate the synthesis of the major core protein of the bovine leukemia virus (BLV) in a naturally infected neoplastic B-cell line.
- [SMAD family proteins: the current knowledge on their expression and potential role in neoplastic diseases].
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