Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

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Summary

It is shown that Tax can perturb Smad-dependent TGF-beta signaling even though no direct interaction of Tax and Smad proteins could be detected, suggesting that the CBP/p300 binding domain of Tax is essential for the suppression of Smad function.

Type
article
Published
2001-04-01
Cited by
101
References
82

Keywords

Political science, Economics

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