Telomerase Regulation and Telomere Maintenance during Human T-cell Leukemia/Lymphoma Virus (HTLV-I) Transformation
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Summary
It is reported that freshly isolated unstimulated adult T-cell leukemia (ATL) cells present high telomerase activity compared to asymptomatic carriers or normal donors and retained shorter telomeres compared to those of uninfected cells isolated from the same patients.
- Type
- dissertation
- Published
- 2008-04-29
- Cited by
- 0
- References
- 88
- OpenAlex
- https://openalex.org/W1946812073
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83819912
Keywords
Telomerase, Telomere, Biology, Leukemia, Cancer research
References
- Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
- Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
- Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T‐cell leukemia
- p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells.
- Allogenic bone marrow transplantation as a treatment for adult T-cell leukemia.
- Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I.
- Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
- Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB.
- Mutations of the p53 gene in adult T-cell leukemia.
- Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples.
- Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia.
- Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.
- Centrosome amplification in adult T‐cell leukemia and human T‐cell leukemia virus type 1 Tax‐induced human T cells
- Suppression of DNA Repair by HTLV Type 1 Tax Correlates with Tax trans-Activation of Proliferating Cell Nuclear Antigen Gene Expression
- The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation
- Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.
- Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia
- Telomeres shorten during ageing of human fibroblasts
- Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms.
- p21Waf1/Cip1/Sdi1 Prevents Apoptosis as Well as Stimulates Growth in Cells Transformed or Immortalized by Human T-Cell Leukemia Virus Type 1-Encoded Tax
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