TGF-β signalling from cell membrane to nucleus through SMAD proteins
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Summary
Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADS that direct transcription to effect the cell's response to TGF-β.
- Type
- review
- Published
- 1997-12-04
- Cited by
- 2,943
- References
- 106
- OpenAlex
- https://openalex.org/W1663371441
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4346492
Keywords
SMAD, Cell biology, Signal transduction, R-SMAD, Nucleus
References
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- Involvement of Extracellular Signal-regulated Kinase 2 and Stress-activated Protein Kinase/Jun N-Terminal Kinase Activation by Transforming Growth Factor β in the Negative Growth Control of Breast Cancer Cells
- Phosphorylation of Ser165 in TGF‐β type I receptor modulates TGF‐β1‐induced cellular responses
Cited by
- Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
- Pioneer axon guidance by UNC-129, a C. elegans TGF-beta.
- Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms
- Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15Ink4b G1 Arrest Pathway
- Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8‐mediated signalling
- Can hair be used to screen for breast cancer?
- Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus.
- Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA
- Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
- Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.
- Myofibroblasts and mechano-regulation of connective tissue remodelling
- Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-β receptor type II
- Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis.
- Smad expression of hepatic stellate cells in liver cirrhosis in vivo and hepatic stellate cell line in vitro
- Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
- TGF-β Signaling Activates Steroid Hormone Receptor Expression during Neuronal Remodeling in the Drosophila Brain
- Glycosylphosphatidylinositol-anchored Proteins Regulate Transforming Growth Factor-β Signaling in Human Keratinocytes*
- Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.
- The role of epithelial-to-mesenchymal transition in renal fibrosis
- Toxoplasma gondii prevents neuron degeneration by interferon-gamma-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-beta1 production by infected microglia.
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