The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells
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Summary
A direct demonstration of the oncogenic potential of the tax gene in nonlymphoid cells is shown and HTLV-I is established as a transforming virus.
- Type
- article
- Published
- 1990-01-01
- Cited by
- 231
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1909549179
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8994375
Keywords
Biology, Transfection, Carcinogenesis, Oncogene, Virology
References
- Human T-cell leukemia virus type I infection of CD4+ or CD8+ cytotoxic T-cell clones results in immortalization with retention of antigen specificity
- Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts
- Intermediate filaments as mechanical integrators of cellular space
- Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.
- Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
- Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element.
- Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials.
- The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice.
- Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
- The roles of individual polyoma virus early proteins in oncogenic transformation
- The action of oncogenes in the cytoplasm and nucleus.
- The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.
- Malignant transformation of early passage rodent cells by a single mutated human oncogene
- A transgenic mouse model for human neurofibromatosis.
- Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.
- High efficiency DNA-mediated transformation of primate cells.
- Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells
- Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines.
- Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.
- Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids.
Cited by
- Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
- Transcriptional Activity of HTLV-I Tax Influences the Expression of Marker Genes Associated with Cellular Transformation
- The HTLV-I Tax oncoprotein: hyper-tasking at the molecular level.
- Transgenic models of HTLV-I mediated disease and latency.
- Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I.
- HTLV-I Tax and cell cycle progression.
- The incidence of factor VIII inhibitors in patients with severe hemophilia A.
- Regulation of HTLV-I oncoprotein Tax by PDLIM2
- Régulation de l’expression des protéines anti-apoptotiques Bfl-1 et Bcl-xL par les protéines virales Tax et HBZ du virus HTLV-1 et identification de petites molécules anti-Bfl-1 à visée thérapeutique
- Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV-I) tax and HTLV-II tax proteins.
- Aspects moléculaires de l'intégration du rétrovirus HTLV-1 et de l'expansion clonale de sa cellule hôte
- Both wild-type and strongly attenuated bovine leukemia viruses protect peripheral blood mononuclear cells from apoptosis
- Temporal regulation of viral and cellular gene expression during human T-lymphotropic virus type I-mediated lymphocyte immortalization
- Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta
- Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcription
- The involvement of retroviruses in human T cell leukaemias and lymphomas
- Ubiquitin Dependent Regulation of Innate Antiviral Signaling
- Expression and characterization of the trans-activating protein Tax of human T-cell leukemia virus type I in Saccharomyces cerevisiae
- Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors
- Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples.
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